Nomograms for the prediction of pathologic stage of clinically localized prostate cancer in Korean men
Nomograms for the prediction of pathologic stage of clinically localized prostate cancer in Korean men
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DOI：
10.3346/jkms.2005.20.2.262
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发表时间：
2005-04-01
影响因子：
4.5
通讯作者：
Ahn, HJ
中科院分区：
文献类型：
--
作者：
Song, C;Kang, TJ;Ahn, HJ
我们分析了1990年6月至2003年11月间在峨山医疗中心接受根治性前列腺切除术的317名患有临床局限性前列腺癌的韩国男性的前列腺癌数据，以构建预测这些肿瘤病理阶段的列线图，并将结果与预先存在的列线图进行比较。采用多项对数线性回归分析，以血清前列腺特异性抗原（PSA）、Gleason评分和临床分期同时预测器官局限性疾病（OCD）、囊外浸润（ECE）、精囊浸润（SVI）和淋巴结转移（LNM）。通过计算受试者工作特征（ROC）曲线下的面积，构建了代表百分比概率的列线图，并与Partin等人提出的列线图进行了比较。手术时的中位血清PSA为10.8 ng/mL，中位活检Gleason评分为7。总体OCD、ECE、SVI和LNM的发生率分别为59.6%、20.5%、11.7%和8.2%，曲线下面积分别为0.724、0.626、0.662和0.794。韩国男性局限性前列腺癌的病理分期可以使用Partin表进行预测，OCD和LNM的准确性可以接受，但ECE和SVI的准确性较低。
We analyzed the prostate cancer data of 317 Korean men with clinically localized prostate cancer who underwent radical prostatectomy at Asan Medical Center between June 1990 and November 2003 to construct nomograms predicting the pathologic stage of these tumors, and compared the outcome with preexisting nomograms. Multinomial log-linear regression was performed for the simultaneous prediction of organ-confined disease (OCD), extracapsular extension (ECE), seminal vesicle invasion (SVI) and lymph node metastasis (LNM) using serum prostate-specific antigen (PSA), Gleason score and clinical stage. Nomograms representing percent probabilities were constructed and compared with those presented by Partin et al. by calculating areas under the receiver operating characteristics (ROC) curves. Median serum PSA at surgery was 10.8 ng/mL, and median biopsy Gleason score was 7. Overall OCD, ECE, SVI and LNM rates were 59.6%, 20.5%, 11.7% and 8.2%, respectively, and areas under the curves were 0.724, 0.626, 0.662, and 0.794, respectively. Pathologic stage of localized prostate cancer in Korean men may be predicted using the Partin table, with acceptable accuracy for OCD and LNM, but less so for ECE and SVI.