Takayasu myocarditis mediated by cytotoxic T lymphocytes
Takayasu myocarditis mediated by cytotoxic T lymphocytes
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DOI：
10.2169/internalmedicine.44.256
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发表时间：
2005-03-01
影响因子：
1.2
通讯作者：
Nagai, R
中科院分区：
文献类型：
--
作者：
Takeda, N;Takahashi, T;Nagai, R
一名15岁的日本男性被转诊评价心力衰竭。常规心力衰竭治疗效果不佳，严重的左心室功能不全和血沉升高持续存在。磁共振血管造影显示主动脉扩张伴管壁增厚是大动脉炎的特征。肌内膜活检标本显示自然杀伤细胞和γ δ T淋巴细胞浸润，在大动脉炎的血管损伤中起主要作用。泼尼松龙给药对心脏功能有很大的益处。这些研究结果表明，类似于动脉组织中的自身免疫细胞毒性机制可能有助于在大动脉炎心脏损害。
A 15-year-old Japanese man was referred for evaluation of heart failure. Conventional heart failure therapy had little effect, and severe left ventricular dysfunction as well as elevated erythrocyte sedimentation rate persisted. Magnetic resonance angiography showed aortic dilatation with wall thickening characteristic of Takayasu's arteritis. An endomyocardial biopsy specimen revealed infiltration of natural killer cells and gamma delta T lymphocytes, which play major roles in vascular injury of Takayasu's arteritis. Prednisolone administration provided great benefits to cardiac function. These findings suggest that autoimmune cytotoxic mechanisms similar to those in arterial tissue may contribute to cardiac impairment in Takayasu's arteritis.