Effects of 5-aminolevulinic acid supplementation on milk production, iron status, and immune response of dairy cows
Effects of 5-aminolevulinic acid supplementation on milk production, iron status, and immune response of dairy cows
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DOI：
10.3168/jds.2018-15982
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发表时间：
2019-12-01
影响因子：
3.5
通讯作者：
Sato, K.
中科院分区：
文献类型：
--
作者：
Hendawy, A. O.;Shirai, M.;Sato, K.
本研究旨在探讨日粮中添加5-氨基乙酰丙酸(5-ALA)对哺乳期奶牛产奶量、乳成分、铁状况和免疫功能的影响。本研究将13头荷斯坦奶牛随机分为对照组和试验组，每公斤干物质添加10毫克5-丙氨酸。在饲养过程中，将5-丙氨酸与少量的总混合日粮混合，并进行顶层处理。实验采用两期交叉设计。每个阶段包括12d的适应期和2d的试验期，饲喂添加5-ALA的日粮的奶牛的白细胞和粒细胞计数均高于对照组。饲喂5-ALA的奶牛外周血单核细胞的吞噬和丝裂原诱导的增殖率均高于基础日粮组。然而，5-ALA不影响铁状态或血浆生化成分。添加5-ALA可提高乳蛋白和乳酪蛋白含量，但对产奶量、乳脂、乳糖、总固形物或非脂固形物含量与对照组相比无明显影响。因此，在奶牛日粮中添加5-丙氨酸可能对乳蛋白合成和免疫应答有积极的作用。
The objective of this study was to investigate the effect of 5-aminolevulinic acid (5-ALA) as a dietary supplement on milk yield and composition as well as iron status and immune response in lactating dairy cows. In this study 13 lactating Holstein cows were randomly assigned to either a control group or a treatment group supplemented with 10 mg of 5-ALA per kilogram of dry matter. During feeding, 5-ALA was mixed with a small amount of the total mixed ration and top-dressed. The experiments followed a crossover design with 2 periods. Each period consisted of an adaptation period of 12 d and a test period of 2 d. Dairy cows fed the diet supplemented with 5-ALA exhibited increased counts of white blood cells and granulocytes compared with the control group. The rate of phagocytosis and mitogen-induced proliferation of peripheral blood mononuclear cells in cows fed 5-ALA were higher than in cows fed a basal diet. However, 5-ALA did not affect iron status or plasma biochemical composition. Supplementation with 5-ALA improved milk protein and milk casein contents; however, it had no effect on milk production, milk fat, lactose, total solids, or solids-not-fat, compared with the control. We conclude that dietary supplementation of 5-ALA to lactating dairy cows may have a positive effect on milk protein synthesis and the immune response.