Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both Platinum(II) and Platinum(IV) complexes
Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both Platinum(II) and Platinum(IV) complexes
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DOI：
10.1021/ja076281t
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发表时间：
2007-11-07
影响因子：
15
通讯作者：
Hambley, Trevor W.
中科院分区：
文献类型：
--
作者：
Alderden, Rebecca A.;Mellor, Howard R.;Hambley, Trevor W.
细胞毒性药物对肿瘤的有限渗透是癌症化疗有效性有限的一个重要因素。在这里，我们已经表明，X射线荧光显微断层扫描是一个合适的技术成像的铂药物分布在多细胞肿瘤球体，实体瘤模型。这揭示了所研究的Pt（II）和Pt（IV）络合物的范围的分布之间没有显著差异，表明可能需要对细胞摄取更具抗性的络合物以确保在整个肿瘤中更完全的分布。
The limited penetration of cytotoxic drugs into tumors is a significant contributing factor to the limited effectiveness of cancer chemotherapy. Here we have shown that X-ray fluorescence microtomography is a suitable technique for imaging the distribution of Pt drugs within multicellular tumor spheroids, models of solid tumors. This has revealed that there is no significant difference between the distributions of the range of Pt(II) and Pt(IV) complexes investigated, suggesting that complexes that are more resistant to cellular uptake may be needed to ensure more complete distribution throughout a tumor.