The serotonin transporter length polymorphism, neuroticism, and depression:: A comprehensive assessment of association
The serotonin transporter length polymorphism, neuroticism, and depression:: A comprehensive assessment of association
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DOI：
10.1016/j.biopsych.2005.04.050
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发表时间：
2005-09-15
影响因子：
10.6
通讯作者：
Flint, J
中科院分区：
文献类型：
--
作者：
Willis-Owen, SAG;Turri, MG;Flint, J
背景：人类5-羟色胺基因（SLC6A4）启动子长度多态性（5-HTTLPR）与情绪表型（如重度抑郁症（MD）和人格、特质神经质(N)）的相关性不一致。人们提出了几种解释来解释这种差异，包括实验设计不足和性别比例、年龄和种族的变化。方法：在这里，我们描述了三个独立的5-HTTLPR位点与样本中N和MD之间的关联测试，用于两个同质群体（h = 88,142和20,921）N评分的极值。统计能力的计算表明，在5%的alpha水平下，这些样本保留100%的能力来检测仅占表型方差5%的遗传效应。年龄的影响从表型测量中回归，性别作为协变量包括在内。结果：与应用的遗传作用方式无关，基因型对N或MD表型均无统计学显著影响（在所有病例中，p >= 0.26）。结论：我们的数据不支持5-HTTLPR变异对艾森克人格问卷N量表或DSM-IV的抑郁症指数的人类情绪有显著贡献的假设。
Background: A promoter-based length polymorphism (5-HTTLPR) of the human serotonin gene (SLC6A4) has exhibited inconsistent association with emotionality phenotypes, such as major depression (MD) and the personality, trait neuroticism (N). Several explanations have been posited to account for this discrepancy, including underpowered experimental design and variation in gender ratio, age, and ethnicity.Methods: Here, we describe three independent tests of association between the 5-HTTLPR locus and both N and MD in samples selected,for extremeness of N-score from two homogenous populations (h = 88,142, and 20,921). Calculations of statistical power indicated that at a 5% alpha level, these samples retain 100% power to detect a genetic effect accounting for just 5% of phenotypic variance. Effects of age were regressed out of the phenotypic measure, and gender was included as a covariate.Results: No statistically significant effects of genotype could be identified on either N or MD phenotypes (in all cases, p >= .26) independently of the genetic mode of action applied.Conclusions: Our data do not support the hypothesis that the 5-HTTLPR variant contributes significantly toward human emotionality as indexed by either the Eysenck Personality Questionnaire N scale or the DSM-IV for MD.