Introduction to Special Issue of Molecular Plant Pathology ‐ “Extracellular and intracellular perception of plant viruses”
Introduction to Special Issue of Molecular Plant Pathology ‐ “Extracellular and intracellular perception of plant viruses”
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分子植物病理学特刊简介—植物病毒的细胞外和细胞内感知
DOI：
10.1111/mpp.12842
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发表时间：
2019
影响因子：
4.9
通讯作者：
Verchot, Jeanmarie
中科院分区：
文献类型：
--
作者：
Aranda, Miguel A.;Mäkinen, Kristiina;Verchot, Jeanmarie
我们很高兴在本期《分子植物病理学》特刊上发表一系列关于“植物病毒的细胞外和细胞内感知”主题的简短评论。本期总结了植物防御病毒的重要突破。近年来取得的重大进展为宿主细胞识别病毒后的抗病毒免疫机制提供了新的见解。植物病毒是造成全球农作物重大损失的重要原因，并威胁粮食安全。植物-病毒相互作用领域的进展将扩大作物育种和工程抗性的潜在策略。本期文章讨论了共同进化的毒力和植物抗性策略，举例说明了病毒与其宿主之间的进化军备竞赛。在过去的二十年里，内源性RNA沉默途径可降解病毒RNA，以及通过核苷酸结合的富含亮氨酸重复序列（NLR）受体对病毒蛋白的细胞内感知，从而导致效应子触发免疫（ETI），被视为植物抗病毒防御的最关键贡献。正如 Meier 等人在题为“植物病毒细胞内感知的观点”的评论中所讨论的。在本期中，这些年来，人们对 NLR 如何感知病毒，以及 NLR 如何激活并使用下游信号通路启动防御反应有了相当多的了解。尽管如此，我们对潜在现象的理解仍然远未完成。经过简明而全面的综述后，作者绘制了未来的研究路线，并指出与合作伙伴复合的 NLR 的结构分析是了解植物病毒的细胞内感知和防御激活的关键信息来源之一。
We are very pleased to present in this Special Issue of Molecular Plant Pathology a series of short reviews on the topic “Extracellular and intracellular perception of plant viruses”. The issue summarizes important breakthroughs in plant defence against viruses. Significant advances made in recent years provide new insights into the mechanisms of antiviral immunity after virus recognition by host cells. Plant viruses constitute an important cause of major crop losses worldwide and threaten food security. The advances in the field of plant–virus interactions will expand the potential strategies for breeding and engineering resistance in crops. The articles in this issue discuss the co-evolving virulence and plant resistance strategies exemplifying the evolutionary arms race between viruses and their hosts. For the past twenty years, the endogenous RNA silencing pathway acting to degrade viral RNAs, and intracellular perception of viral proteins by nucleotide-binding leucine-rich repeat (NLR) receptors leading to effector-triggered immunity (ETI), have been seen as the most critical contributions to antiviral defence in plants. As discussed in the review entitled “Perspectives on intracellular perception of plant viruses” by Meier et al. in this issue, a considerable body of knowledge on how viruses are perceived by NLRs, and how NLRs are activated and use downstream signalling pathways to initiate defence responses, has developed during these years. In spite of that, our understanding of the underlying phenomena is still far from complete. After their concise but comprehensive review, the authors draw future lines for research, and point out structural analyses of NLRs complexed with their partners as one source of critical information to understand intracellular perception of plant virus and defences activation.