Identification and Implications of HIV-1 CRF01_AE Subtype in Hawai'i.
Identification and Implications of HIV-1 CRF01_AE Subtype in Hawai'i.
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发表时间：
2022-08
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通讯作者：
Logan S. Dean;I. SahBandar;C. Shikuma
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作者：
Logan S. Dean;I. SahBandar;C. Shikuma
人类免疫缺陷病毒具有高度的遗传变异倾向，其复杂的系统发育和亚型的多样性证明了这一点。 B 亚型在北美和夏威夷占主导地位，而 CRF01_AE 在菲律宾和东南亚超过 50% 的病例中发现。在夏威夷艾滋病中心和菲律宾总医院之间的一项小型合作研究中，对艾滋病毒+参与者进行了分子系统发育亚型分析。来自夏威夷队列的 15 名参与者中的 2 名 (13%) 和来自菲律宾队列的 21 名参与者中的 12 名 (57%) 被确定为 HIV-1 的 CRF01_AE 亚型，其余参与者被确定为 B 亚型。夏威夷的一名患有 CRF01_AE 的个体是从菲律宾移民的，而来自夏威夷的另一名患有 CRF01_AE 亚型的参与者是当地人，在夏威夷出生和长大。作者报告说，夏威夷的艾滋病毒亚型多样性可能会增加，并讨论了其潜在的临床和公共卫生影响。
Human Immunodeficiency Virus has a high propensity for genetic variation, demonstrated by its complex phylogeny and multiplicity of subtypes. Subtype B is predominant in North America as well as in Hawai'i while CRF01_AE is found in over 50% of cases in the Philippines and Southeast Asia. In a small collaborative study between the Hawai'i Center for AIDS and Philippines General Hospital, molecular phylogenetic subtyping was conducted on HIV+ participants. Two of 15 (13%) participants from the Hawai'i cohort and 12 of 21 (57%) participants from the Philippines cohort were identified as having CRF01_AE subtype of HIV-1, with remaining participants identified as subtype B. While one individual in Hawai'i with CRF01_AE had emigrated from the Philippines, the other participant from Hawai'i with CRF01_AE subtype was a local individual, born and raised in Hawai'i. The authors report that HIV subtype diversity may be increased in Hawai'i and discuss its potential clinical and public health implications.