Total synthesis of diospongin A via an enzymatic kinetic resolution of (±)-tetrahydropyranol derived from Prins cyclization
Total synthesis of diospongin A via an enzymatic kinetic resolution of (±)-tetrahydropyranol derived from Prins cyclization
复制标题
通过 Prins 环化衍生的 (±)-四氢吡喃醇的酶促动力学拆分全合成薯海绵素 A
作者：
J. Yadav;B. Padmavani;B. Reddy;Ch. Venugopal;A. Rao
介绍了一种简洁高效的全合成方法，该方法以Prins环合反应和酶促动力学复溶为关键步骤。本文首次报道了利用Prins环化反应中的（±）-四氢吡喃醇通过脂肪酶介导的酯交换反应合成-diospongin A。
A concise and efficient total synthesis of diospongin A is described; it utilizes Prins cyclization and enzymatic kinetic re-solution as key steps. This is the first report on the synthesis of -diospongin A by means of lipase-mediated transesterification of (±)-tetrahydropyranol derived from Prins cyclization.