IDENTIFICATION OF A NON-H-2 GENE (RFV-3) INFLUENCING RECOVERY FROM VIREMIA AND LEUKEMIA INDUCED BY FRIEND VIRUS COMPLEX
IDENTIFICATION OF A NON-H-2 GENE (RFV-3) INFLUENCING RECOVERY FROM VIREMIA AND LEUKEMIA INDUCED BY FRIEND VIRUS COMPLEX
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DOI：
10.1073/pnas.76.1.425
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
WEHRLY, K
中科院分区：
文献类型：
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作者：
CHESEBRO, B;WEHRLY, K
H-2b/b 小鼠中，弗兰德病毒 [FV] 复合物诱导的病毒血症和白血病的恢复需要单个常染色体非 H-2 基因 (Rfv-3) 的显性 C57BL/10 等位基因。在 H-2a/a 小鼠中，Rfv-3 基因明显影响持续性白血病存在下的病毒血症恢复，因为这些小鼠缺乏从白血病恢复所需的适当 H-2 基因型。 Rfv-3 基因与 Fv-2 基因不同，因为在具有 Fv-2s/s 基因型的重组近交小鼠中观察到病毒血症恢复。回交研究表明Rfv-3 和Fv-2 没有连锁。 Rfv-3 基因可能通过影响特异性抗 FV 体液抗体反应来发挥作用。
The dominant C57BL/10 allele of a single, autosomal, non-H-2 gene (Rfv-3) was required for recovery from viremia and leukemia induced by Friend virus [FV] complex in H-2b/b mice. In H-2a/a mice, the Rfv-3 gene apparently influenced recovery from viremia in the presence of persistent leukemia because these mice lacked the appropriate H-2 genotype for recovery from leukemia. The Rfv-3 gene was distinct from the Fv-2 gene because recovery from viremia was seen in recombinant-inbred mice with the Fv-2s/s genotype. Backcross studies indicated that Rfv-3 and Fv-2 were not linked. The Rfv-3 gene may act by influencing the specific anti-FV humoral antibody response.