Chronic granulocytic leukemia without the Philadelphia chromosome.
Chronic granulocytic leukemia without the Philadelphia chromosome.
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无费城染色体的慢性粒细胞白血病。
DOI：
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发表时间：
1976
影响因子：
3.5
通讯作者：
V. Devita
中科院分区：
文献类型：
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作者：
G. Canellos;J. Whang‐Peng;V. Devita
自1961年以来，对美国国家癌症研究所收治的230例慢性粒细胞白血病（CGL）患者进行了骨髓细胞遗传学研究。20例患者缺乏费城（Ph1）染色体。所有患者此前均未接受治疗。与ph1阳性患者相比，伴有ph1阴性疾病的CGL患者的中位年龄（60岁比42岁）更高，并且诊断时的中位白细胞（75,000）和血小板计数（170,000）更低。他们对化疗的反应通常很差，中位生存期为15个月，而ph1阳性组为44个月。4例患者存活5年以上，2例存活10年以上。35%的ph1阴性患者有不同比例的非整倍体细胞系。具有CGL血液学特征的患者缺少Ph1染色体是一个不良的预后迹象。
Cytogenetic studies of bone marrow were performed in 230 consecutive cases of patients with chronic granulocytic leukemia (CGL) admitted to the National Cancer Institute since 1961. Twenty patients lacked the Philadelphia (Ph1) chromosome. All were previously untreated. When compared with Ph1-positive patients, CGL patients with Ph1-negative disease had a higher median age (60 compared with 42 years) and were diagnosed at lower median leukocyte (75,000) and platelet counts (170,000). Their response to chemotherapy was generally poor, with a median survival of 15 months compared with 44 months for the Ph1-positive group. Four patients survived more than 5 years and two, more than 10 years. Thirty-five per cent of the Ph1-negative patients had aneuploid cell lines of various percentages. Absence of the Ph1 chromosome in patients with the hematologic characteristics of CGL is a bad prognostic sign.