Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.
Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.
复制标题
砷化铟和磷化铟对仓鼠肺部的慢性毒性。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
N. Ishinishi
中科院分区：
文献类型：
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作者：
A. Tanaka;A. Hisanaga;M. Hirata;M. Omura;Y. Makita;N. Inoue;N. Ishinishi
研究了砷化铟(InAs)和磷化铟(InP)对雄性叙利亚金黄地鼠的慢性毒性作用。金黄地鼠吸入含总剂量为7.5 mg砷或磷的InAs或InP颗粒，每周一次，持续15周。作为对照，仓鼠被用磷酸盐缓冲液处理。在仓鼠的整个生命周期中，与对照组相比，InAs组仓鼠的累积增重显著受到抑制，而InP组与对照组相比则无显著差异。在肺组织病理改变方面，InAs或InP组蛋白沉积样病变、肺泡或细支气管细胞增生、肺炎、肺气肿和化生骨化的发生率明显高于对照组。从这些结果来看，InAs和InP似乎对仓鼠的肺造成了严重的损害。
Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.