SPLITTING OF CIS-SYN CYCLOBUTANE THYMINE-THYMINE DIMERS BY RADIOLYSIS AND ITS RELEVANCE TO ENZYMATIC PHOTOREACTIVATION
SPLITTING OF CIS-SYN CYCLOBUTANE THYMINE-THYMINE DIMERS BY RADIOLYSIS AND ITS RELEVANCE TO ENZYMATIC PHOTOREACTIVATION
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DOI：
10.1080/09553009214551941
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发表时间：
1992-08-01
影响因子：
2.6
通讯作者：
SANCAR, A
中科院分区：
文献类型：
--
作者：
HEELIS, PF;DEEBLE, DJ;SANCAR, A
本文研究了水溶液中顺式胸腺嘧啶-胸腺嘧啶环丁烷型二聚体的~（137）Cs辐照。胸腺嘧啶二聚体被e（aq）-、CO2-、哦，SO4-，Br2.-，和异丙醇自由基进行了研究，采用高压液相色谱法（HPLC）。证据表明，单电子还原剂研究诱导二聚体裂解部分链反应。胸腺嘧啶-胸腺嘧啶的单电子还原电位的近似值，并提出热力学计算，以预测在酶光复活的情况下的电子转移的方向。
The Cs-137-gamma-irradiation of cis-syn thymine-thymine cyclobutane type dimers has been studied in aqueous solution. The mechanism of thymine dimer cleavage by e(aq)-, CO2.-, OH.,SO4.-, Br2.-, and isopropanol radicals was studied using high pressure liquid chromatography (HPLC). Evidence that the one-electron reductants studied induce dimer cleavage partially by a chain reaction is presented. Approximate values for the one-electron reduction potential of thymine-thymine are obtained and thermodynamic calculations are presented in order to predict the direction of electron transfer in the case of enzymatic photoreactivation.