Linkage disequilibrium and persistence of phase in Holstein-Friesian, Jersey and Angus cattle
Linkage disequilibrium and persistence of phase in Holstein-Friesian, Jersey and Angus cattle
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DOI：
10.1534/genetics.107.084301
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发表时间：
2008-07-01
期刊：
影响因子：
3.3
通讯作者：
Goddard, M. E.
中科院分区：
文献类型：
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作者：
de Roos, A. P. W.;Hayes, B. J.;Goddard, M. E.
当一个遗传标记和一个数量性状基因座（QTL）在一个群体中处于连锁不平衡（LD）时，它们在另一个群体中可能不处于LD或它们的LD相可能被接收。本研究的目的是比较多个牛群体中LD的程度和LD期的持续性。使用全基因组单核苷酸多态性（SNP）计算同线标记对的LD测量值r和r（2），这些SNP在荷兰和澳大利亚荷斯坦-弗里斯兰（HF）公牛、澳大利亚安格斯牛、新西兰弗里斯兰和泽西奶牛中进行基因分型。在标记距离10、20、40、100和1000 kb处，平均r（2）分别为0.35、0.25、0.22、0.14和0.06，这表明相邻标记之间r（2）>= 0.20的牛品种内的基因组选择将需要类似于50，000个SNP。对于非常接近的标记对，相同标记对的群体间r值的相关性接近1（
When a genetic marker and a quatitative trait locus (QTL) are in linkage disequilibrium (LD) in one population, they may not be in LD in another population or their LD phase may be received. The objectives of this study were to compare the extent of LD and the persistence of LD phase across multiple cattle populations. LD measures r and r(2) were calculated for syntenic marker pairs using genomewide single-nucleotide polymorphisms (SNP) that were genotyped in Dutch and Australian Holstein-Friesian (HF) bulls, Australian Angus cattle, and New Zealand Friesian and Jersey cows. Average r(2) was similar to 0.35, 0.25, 0.22, 0.14, and 0.06 at marker distances 10, 20, 40, 100, and 1000 kb, respectively, which indicates that genomic selection within cattle breeds with r(2) >= 0.20 between adjacent markers would require similar to 50,000 SNPs. The correlation of r values between populations for the same marker pairs was close to 1 for pairs of very close markers (