5-HT3 receptor antagonists attenuate cocaine-induced locomotion in mice.
5-HT3 receptor antagonists attenuate cocaine-induced locomotion in mice.
复制标题
5-HT3 受体拮抗剂可减弱可卡因诱导的小鼠运动。
DOI：
10.1016/0014-2999(90)90454-e
复制
发表时间：
1990
影响因子：
5
通讯作者：
Reith,ME
中科院分区：
文献类型：
--
作者：
Reith,ME
5-HT3受体拮抗剂ICS 205-930和扎可必利可减弱可卡因诱导的C57BL/6ByJ小鼠的运动活动。相反，选择性的5-HT1和5-HT2受体拮抗剂甲基丝氨酸甲酯不影响可卡因的反应。5-HT3受体拮抗剂的作用不是由于全身镇静，因为扎可必利不会改变对咖啡因的运动反应。
The 5-HT3receptor antagonists ICS 205–930 and zacopride attenuated cocaine-induced locomotor activity in C57BL/6ByJ mice. In contrast, the aselective 5-HT1and 5-HT2receptor antagonist, methysergide did not affect the response to cocaine. The effect of the 5-HT3receptor antagonists was not due to general sedation, because zacopride did not alter the locomotor response to caffeine.