MOLECULAR-CLONING AND SEQUENCING OF THE GENE ENCODING HUMAN ANGIOTENSIN-II TYPE-1 RECEPTOR
MOLECULAR-CLONING AND SEQUENCING OF THE GENE ENCODING HUMAN ANGIOTENSIN-II TYPE-1 RECEPTOR
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DOI：
10.1016/0006-291x(92)91600-u
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发表时间：
1992-02-28
影响因子：
3.1
通讯作者：
INAGAMI, T
中科院分区：
文献类型：
--
作者：
FURUTA, H;GUO, DF;INAGAMI, T
从淋巴细胞基因组文库中克隆了人血管紧张素Ⅱ1型受体(AT1)基因。人类AT1受体基因的编码区包含在该基因的单个外显子编码片段中，表明编码区的结构是无内含子的。人AT1受体的氨基酸序列由其碱基序列推定，含有359个氨基酸，与牛和大鼠的AT1受体序列具有高度的同源性。人类AT1受体的氨基酸替换主要局限于分子的羧基末端半部分。在这些序列中，七个跨膜结构域非常保守。
The gene of human angiotensin II type 1 (AT1) receptor was isolated from a lymphocyte genomic library. The coding region of the human AT1receptor gene was contained in a single exon coding segment of the gene indicating an intronless structure of the coding region. The amino acid sequence of human AT1receptor deduced from its base sequence has 359 amino acids and showed a high degree of sequence identity to bovine and rat AT1receptor sequences. Amino acid substitutions specific to the human AT1receptor were mostly confined to the carboxy terminal half of the molecule. The seven-transmembrane domains are well-conserved in those sequences.