Effects of chitosan-stabilized selenium nanoparticles on cell proliferation, apoptosis and cell cycle pattern in HepG2 cells: Comparison with other selenospecies
Effects of chitosan-stabilized selenium nanoparticles on cell proliferation, apoptosis and cell cycle pattern in HepG2 cells: Comparison with other selenospecies
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DOI：
10.1016/j.colsurfb.2014.06.062
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发表时间：
2014-10-01
影响因子：
5.8
通讯作者：
Camara, Carmen
中科院分区：
文献类型：
--
作者：
Estevez, Hector;Carlos Garcia-Lidon, J.;Camara, Carmen
硒是一种重要的元素，在许多生物功能中起着重要作用。许多研究报道了硒摄入对癌症治疗和预防的潜在有益作用，这不仅是剂量依赖性的，而且与特定硒种的性质密切相关。纳米硒被认为是一种具有优异抗氧化性能的新型硒化合物；然而，与其他研究充分的硒物种相比，硒纳米粒子的特性知之甚少。在这里，我们结合不同独立的生物分析方法，在体外模型中比较了硒纳米颗粒和其他硒化合物（无机和有机硒种）的作用。通过对HepG2细胞增殖、细胞凋亡和细胞周期模式等不同参数的生物分析表征，表明了这种相对较新的化合物的独特性质，为未来作为化疗药物的应用提供了支持和完善的证据。(C) 2014 Elsevier B.V.版权所有
Selenium is an essential element that plays an important role in many biological functions. Many studies have reported the potential beneficial effects of Se intake for cancer therapy and prevention, which are not only dose-dependent but also closely related to the properties of specific selenospecies. Selenium nanoparticles are considered a novel selenium compound with excellent antioxidant properties; however, little is known about the properties of selenium nanoparticles in comparison to other well-studied selenospecies. Here, we combined different independent bioanalytical approaches to carry out a comparison between the effects of selenium nanoparticles and other selenocompounds (inorganic and organic selenospecies) using an in-vitro model. The bioanalytical characterization of different parameters such as cell proliferation, apoptosis and cell cycle pattern on HepG2 cells has shown the unique properties of this relatively novel compound that support and complete prior evidences for future applications as chemotherapeutic agent. (C) 2014 Elsevier B.V. All rights reserved.