Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesophageal squamous carcinoma cell line Eca109 cells
Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesophageal squamous carcinoma cell line Eca109 cells
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DOI：
10.1042/cbi20090419
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发表时间：
2011-05-01
影响因子：
3.9
通讯作者：
Shi, Ruihua
中科院分区：
文献类型：
--
作者：
Feng, Yadong;Zhu, Hong;Shi, Ruihua
缺氧诱导因子-1α(HIF-1α)被认为促进了食道鳞癌的生长。因此，HIF-1α抑制剂被视为治疗食道癌的靶点。近年来，YC-1[3-(5‘-hydroxymethyl-2’-furyl)-1-benzylindazole]作为一种潜在的HIF-1α抑制剂得到了广泛的应用，并正在被开发为一种新型的抗癌药物。然而，对YC-1在人类食道癌中的作用知之甚少。在本研究中，我们旨在研究这些效应在食管鳞癌细胞系，即Eca109细胞。我们发现YC-1取消了缺氧诱导的HIF-1α的上调。YC-1抑制Eca109细胞生长，抑制细胞迁移活性。这些结果提示YC-1可能是一种治疗食管鳞癌的候选化疗药物。
HIF-1 alpha: (hypoxia-inducible factor 1 alpha) is believed to promote oesophageal squamous tumour growth. Thus, an HIF-1 alpha inhibitor is viewed as a therapeutic target in treating oesophageal cancer. Recently, YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] has been widely used as a potential HIF-1 alpha inhibitor and is being developed as a novel anticancer drug. However, little is known about the effects of YC-1 in human oesophageal cancer. In the present study, we aimed to investigate these effects in an esophageal squamous cancer cell line; i.e. Eca109 cells. We found that YC-1 abolished the hypoxia-induced up-regulation of HIF-1 alpha. YC-1 arrested cell growth and inhibited cell migration activities in Eca109 cells. These results suggest that YC-1 may be a chemotherapy candidate against oesophageal squamous cancers.