Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome
Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome
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DOI：
10.1001/archpsyc.57.4.331
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发表时间：
2000-04-01
影响因子：
--
通讯作者：
Gore, JC
中科院分区：
文献类型：
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作者：
Schultz, RT;Gauthier, I;Gore, JC
背景：对个人面孔的识别是人际互动和社会群体中成功运作的重要组成部分。因此，自闭症及相关疾病的个体在人脸识别方面存在选择性缺陷(不包括非人脸物体识别)是相当有意义的。方法：我们使用功能磁共振成像(FMRI)研究了14例高功能自闭症或Asperger综合征患者(自闭症组)的面孔和下级物体知觉，并与两组匹配的正常对照组(正常对照组1[NC1]和正常对照组2[NC2])(n=14)进行了比较。在NC2中定义感兴趣区(ROI)，然后将其应用于NC2与自闭症组之间的比较。结果：在第一组比较中，我们发现任务X组对右侧梭形回(FC)和右侧颞下回(ITG)的激活大小存在显著的交互作用。事后分析表明，在辨别面孔(但不是物体)时，自闭症组右侧ITG的激活程度显著高于对照组，而右侧FG的激活程度低于对照组。重复研究再次表明，与对照组相比，自闭症组在处理面孔时使用ITG的次数明显更多，但对于这些分析，影响现在是在左侧。结论：自闭症谱系障碍患者在面孔辨别过程中表现出一种大脑活动模式，这与更典型的非面孔物体感知的基于特征的策略是一致的。
Background: Recognition of individual faces is an integral part of both interpersonal interactions and successful functioning within a social group. Therefore, it is of considerable interest that individuals with autism and related conditions have selective deficits in face recognition (sparing nonface object recognition).Method: We used functional magnetic resonance imaging (fMRI) to study face and subordinate-level object perception in 14 high-functioning individuals with autism or Asperger syndrome (the autism group), in comparison with 2 groups of matched normal controls (normal control group 1 [NC1] and normal control group 2 [NC2]) (n = 14 for each). Regions of interest (ROIs) were defined in NC1 and then applied in comparisons between NC2 and the autism group. Regions of interest were also defined in NC2 and then applied to comparisons between NC1 and the autism group as a replication study.Results: In the first set of comparisons, we found significant task X group interactions for the size of activation in the right fusiform gyrus (FC) and right inferior temporal gyri (ITG). Post hoc analyses showed that during face (but not object) discrimination, the autism group had significantly greater activation than controls in the right ITG and less activation of the right FG. The replication study showed again that the autism group used the ITG significantly more for processing faces than the control groups, but for these analyses, the effect was now on the left side. Greater ITG activation was the pattern found in both control groups during object processing.Conclusions: Individuals with autism spectrum disorders demonstrate a pattern of brain activity during face discrimination that is consistent with feature-based strategies that are more typical of nonface object perception.