Reduced cortical γ-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy
Reduced cortical γ-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy
复制标题
DOI：
10.1001/archpsyc.56.11.1043
复制
发表时间：
1999-11-01
影响因子：
--
通讯作者：
Krystal, JH
中科院分区：
文献类型：
--
作者：
Sanacora, G;Mason, GF;Krystal, JH
背景：一些新出现的证据表明γ -氨基丁酸（GABA）系统的功能障碍与重度抑郁症有关。然而，由于难以获得无创的体内脑GABA水平测量，这一假设的研究受到限制。在这项研究中，我们使用体内质子磁共振波谱来研究GABA神经递质系统异常与抑郁症的神经生物学过程有关的假设。方法：采用局部差异编辑质子磁共振波谱法测量符合DSM-IV标准的无药物抑郁症患者（n = 14）和无精神病史的健康对照（n = 18）枕皮质GABA水平。采用协方差分析来检验抑郁、性别和年龄的影响。结果：抑郁症患者枕皮质GABA水平较健康组显著降低（52%）。虽然有明显的年龄和性别影响，但诊断与年龄或性别都没有相互作用。结论：本研究首次提供了抑郁症患者大脑皮层GABA浓度异常低的证据。
Background: Several lines of emerging evidence suggest that dysfunction of gamma-aminobutyric acid (GABA) systems is associated with major depression. However, investigation of this hypothesis is limited by difficulty obtaining noninvasive in vivo measures of brain GABA levels. In this study we used in vivo proton magnetic resonance spectroscopy to investigate the hypothesis that abnormalities in the GABA neurotransmitter system are associated with the neurobiologic processes of depression.Methods: The GABA levels were measured in the occipital cortex of medication-free depressed patients meeting DSM-IV criteria (n = 14) and healthy control subjects with no history of mental illness (n = 18) using a localized difference editing proton magneticresonance spectroscopy protocol. An analysis of covariance was employed to examine the effects of depression, sex, and age.Results: The depressed patients demonstrated a highly significant (52%) reduction in occipital cortex GABA levels compared with the group of healthy subjects. While there were significant age and sex effects, there was no interaction of diagnosis with either age or sex.Conclusion: This study provides the first evidence of abnormally low cortical GABA concentrations in the brains of depressed patients.