Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules
Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules
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DOI：
10.1186/s40644-019-0219-3
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发表时间：
2019-06-07
期刊：
影响因子：
4.9
通讯作者：
Naganawa, Shinji
中科院分区：
文献类型：
--
作者：
Iwano, Shingo;Umakoshi, Hiroyasu;Naganawa, Shinji
背景对于亚实性非小细胞肺癌（subsolid non-small cell lung cancer，NSCLCs），实体大小（solid size，SS）是实体成分的最大直径，与肿瘤预后的相关性比总大小（total size）更准确，总大小是整个肿瘤的最大直径，包括磨玻璃样阴影。方法回顾性分析我院2010 - 2013年NSCLC患者术前影像学、临床资料及病理报告，选取临床分期（c-Stage）0期和I期肿瘤。无病生存期（DFS），生存分析的基础上，被用来评估肿瘤的特点，预测projective.ResultsA在231例患者（88名女性和143名男性，年龄，677岁），共247个非小细胞肺癌诊断被列入我们的队列。其中实性结节131例，亚实性结节116例。DFS曲线表明，预后按以下顺序显著更差：c-0期、c-IA期和c-IB期肿瘤（p=0.016）。实性结节患者的预后明显差于亚实性结节患者（p
BackgroundFor subsolid non-small cell lung cancers (NSCLCs), solid size (SS), which is the maximal diameter of the solid component, correlates more accurately with tumor prognosis than the total size, which is the maximal diameter of the entire tumor, including ground-glass opacity. We reviewed the propriety of the TNM staging based on the SS for early-stage NSCLCs.MethodsWe retrospectively reviewed the preoperative radiological reports, clinical records, and pathological reports of NSCLC cases in our hospital between 2010 and 2013, and clinical stage (c-Stage) 0 and I tumors were selected. Disease-free survival (DFS), based on survival analysis, was used to assess the tumor characteristics that predicted the prognosis.ResultsA total of 247 NSCLC diagnoses in 231 patients (88 women and 143 men; age, 677years) were included in our cohort. They were classified into solid (n=131) and subsolid (n=116) nodules. The DFS curves indicated that prognosis was significantly worse in the following order: c-Stage 0, c-Stage IA, and c-Stage IB tumors (p=0.016). Patients with solid nodules showed a significantly worse prognosis than patients with subsolid nodules (p