THE NUCLEUS BASALIS OF MEYNERT IN NEUROLOGICAL DISEASE - A QUANTITATIVE MORPHOLOGICAL-STUDY
THE NUCLEUS BASALIS OF MEYNERT IN NEUROLOGICAL DISEASE - A QUANTITATIVE MORPHOLOGICAL-STUDY
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DOI：
10.1002/ana.410170210
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发表时间：
1985-01-01
影响因子：
11.2
通讯作者：
MIRRA, SS
中科院分区：
文献类型：
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作者：
ROGERS, JD;BROGAN, D;MIRRA, SS
最近在阿尔茨海默病的Meynert基底核（nbM）中发现神经元变性，提示该核和胆碱能系统在痴呆疾病中可能起作用。在38个编码的大脑中的nbM的2个解剖水平的神经元群体和密度进行了评估，这些大脑来自患有各种神经系统疾病的患者。最显著的nbM变性见于阿尔茨海默病和帕金森病。在传染性痴呆克雅氏病和进行性核上性麻痹中发现了神经元的中间损失。肌萎缩侧索硬化症和多发性硬化症通常是非痴呆性疾病，其细胞计数与对照组的非痴呆性脑血管疾病患者相当。nbM中还发现了阿尔茨海默病、帕金森病和克雅氏病的特征性神经病理改变、进行性核上性麻痹和亚急性硬化性全脑炎。大多数以前的nbM研究都是基于与对照组相比的少数病例。在本大系列中，采用了一致的方法和多重比较统计程序，以避免过度报告统计学显著性。证实了阿尔茨海默病中nbM的显著变性。这种退化在精神错乱和非精神错乱的神经系统疾病的范围内被放置在透视中。需要更大的病例研究，使用适当的统计技术进行多组比较，以确定nbM变性在神经系统疾病中的意义。
The recent finding of neuronal degeneration in the nucleus basalis of Meynert (nbM) in Alzheimer''s disease suggests a possible role of this nucleus and the cholinergic system in dementing illness. Neuronal population and density were assessed in 2 anatomical levels of the nbM in 38 coded brains from patients with a broad variety of neurological disorders. The most striking nbM degeneration was found in Alzheimer''s and Parkinson''s diseases. An intermediate loss of neurons was noted in the transmissible dementia Creutzfeldt-Jakob disease and in progressive supranuclear palsy. The usually nondementing diseases amyotrophic lateral sclerosis and multiple sclerosis showed cell counts comparable to those in a control group of nondemented patients with cerebrovascular disease. Characteristic neuropathological changes of Alzheimer''s, Parkinson''s and Creutzfeldt-Jakob diseases, progressive supranuclear palsy and subacute sclerosing panencephalitis were also found in the nbM. Most previous studies of the nbM have been based on small numbers of cases compared with controls. In the present large series consistent methodology and a multiple-comparison statistical procedure were used to avoid overreporting of statistical significance. The marked degeneration of the nbM in Alzheimer''s disease is confirmed. such degeneration is placed into perspective in a spectrum of dementing and nondementing neurological diseases. Larger case studies, using appropriate statistical techniques for multiple group comparisons, are needed to establish the significance of nbM degeneration in neurological disease.