EVIDENCE FOR REFLEX UPPER AIRWAY DILATOR MUSCLE ACTIVATION BY SUDDEN NEGATIVE AIRWAY PRESSURE IN MAN
EVIDENCE FOR REFLEX UPPER AIRWAY DILATOR MUSCLE ACTIVATION BY SUDDEN NEGATIVE AIRWAY PRESSURE IN MAN
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DOI：
10.1113/jphysiol.1991.sp018536
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发表时间：
1991-05-01
影响因子：
5.5
通讯作者：
GUZ, A
中科院分区：
文献类型：
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作者：
HORNER, RL;INNES, JA;GUZ, A
1. 为了确定上气道负压是否引起反射性咽扩张肌激活，我们使用口内双极表面电极记录 10 名正常、意识清醒、仰卧受试者对 0、-2.5、-5、-15、-25 和 -35 cmH2O（0-90% 上升时间 < 30 ms）持续 500 ms 压力刺激的颏舌肌肌电图 (EMG) 活动。2. 当受试者在呼气末放松时，在三种情况下施加刺激：（i）声门打开（GO），（ii）声门关闭（GC）和（iii）嘴巴和鼻子关闭的对照。3。 对每个实验条件下的每个压力进行六个校正和集成的肌电图响应的分箱平均。 反应潜伏期定义为肌电图活动显着增加至刺激前水平以上的时间。 反应幅度量化为刺激后 80 毫秒与刺激前 80 毫秒的肌电图活动之比；未分析受试者的自主反应时间（伸出舌头）后的数据。4． 气道负压激活颏舌肌。 激活的中位潜伏期（34 毫秒）比表明反射反应的自愿激活时间（184 毫秒）快得多。5。 与 0 cmH2O 对照和嘴巴和鼻子闭合的对照相比，在至少 -5 cmH2O (GC) 和 -15 cmH2O (GO) 的压力下发生显着激活。 在 -25 和 -35 cmH2O 条件下，GO 的响应明显高于 GC.6。 不同受试者的反应幅度（“强度”）不同；这些差异是可重复的。7。 我们得出的结论是，气道负压会导致人类反射性咽部扩张肌激活。 GC 的反应表明上气道受体可以介导该反应，但 GO 的较大反应表明声门下受体的贡献。
1. To determine if negative upper airway pressure causes reflex pharyngeal dilator muscle activation, we used intra-oral bipolar surface electrodes to record genioglossus electromyogram (EMG) activity in response to 500 ms duration pressure stimuli of 0, -2.5, -5, -15, -25 and -35 cmH2O (0-90% rise time < 30 ms) in ten normal, conscious, supine subjects.2. With the subjects relaxed at end-expiration, stimuli were applied in each of three conditions: (i) glottis open (GO), (ii) glottis closed (GC) and (iii) controls with the mouth and nose closed.3. Six rectified and integrated EMG responses were bin averaged for each pressure in each experimental condition. Response latency was defined as the time when the EMG activity significantly increased above pre-stimulus levels. Response magnitude was quantified as the ratio of the EMG activity for 80 ms post-stimulus to 80 ms pre-stimulus; data from after the subject's voluntary reaction time (for tongue protrusion) were not analysed.4. Negative airway pressure activated the genioglossus. The median latency of activation (34 ms) was much faster than the time for voluntary activation (184 ms) indicating a reflex response.5. Significant activation, compared to 0 cmH2O controls and controls with mouth and nose closed, occurred with pressures of at least -5 cmH2O (GC) and -15 cmH2O (GO). At -25 and -35 cmH2O, responses with GO were significantly greater than with GC.6. The magnitude ('strength') of the responses differed between subjects; these differences were repeatable.7. We conclude that negative airway pressure causes reflex pharyngeal dilator muscle activation in man. Responses with GC suggest that upper airway receptors can mediate the response but larger responses with GO indicate a contribution from subglottal receptors.