Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers.
Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers.
复制标题
持续募集的幼稚T细胞有助于生发中心的卵泡助手和调节T细胞池。
DOI：
10.1038/s41467-023-41880-9
复制
发表时间：
2023-10-31
影响因子：
16.6
通讯作者：
Nussenzweig, Michel C.
中科院分区：
文献类型：
--
作者：
Merkenschlager, Julia;Berz, Riza-Maria;Ramos, Victor;Uhlig, Maximilian;Maclean, Andrew J.;Nowosad, Carla R.;Oliveira, Thiago Y.;Nussenzweig, Michel C.
滤泡辅助性T细胞（TFH）介导生发中心（GCs）的B细胞选择和克隆扩增，而滤泡调节性T细胞（TFR）阻止自反应性B细胞的出现并帮助消除反应。在这里，我们发现GC反应持续地从naïve常规和初始胸腺调节性T细胞（Treg）库中招募T细胞。在GC早期，新募集的T细胞发育为TFH，而在收缩期进入的细胞发育为TFR细胞，有助于GC溶解。TFR的命运决定与抗原可用性降低有关，并受缓慢抗原递送或mRNA疫苗接种的调节。因此，新发展的TFH和TFR侵入正在进行的GC有助于根据抗原可用性重塑GC。B细胞克隆扩增和亲和成熟发生在生发中心（GC），并由滤泡T细胞协调。本文作者发现naïve在GC反应过程中，常规T细胞不断被招募到GC中，并发展成滤泡辅助和调节性T细胞，从而定量地参与了GC的重构。
Follicular helper T cells (TFH) mediate B cell selection and clonal expansion in germinal centers (GCs), and follicular regulatory T cells (TFR) prevent the emergence of self-reactive B cells and help to extinguish the reaction. Here we show that GC reactions continually recruit T cells from both the naïve conventional and naive thymic regulatory T cell (Treg) repertoires. In the early GC, newly recruited T cells develop into TFH, whereas cells entering during the contraction phase develop into TFR cells that contribute to GC dissolution. The TFR fate decision is associated with decreased antigen availability and is modulated by slow antigen delivery or mRNA vaccination. Thus, invasion of ongoing GCs by newly developing TFH and TFR helps remodel the GC based on antigen availability. B cell clonal expansion and affinity maturation takes place in germinal centers (GC) and is orchestrated by follicular T cells. Here authors show that naïve conventional T cells are continuously recruited to the GCs during the GC reaction and develop into follicular helper and regulatory T cells, thus quantitatively contribute to remodelling the GC overtime.
登录
查看更多内容
影响因子：
30.5
作者：
Clement, Rachel L.;Daccache, Joe;Sage, Peter T.
通讯作者：
Sage, Peter T.
DOI：
10.1126/science.aac4919
发表时间：
2015-08-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gitlin AD;Mayer CT;Oliveira TY;Shulman Z;Jones MJ;Koren A;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
16.6
作者：
Merkenschlager J;Ploquin MJ;Eksmond U;Andargachew R;Thorborn G;Filby A;Pepper M;Evavold B;Kassiotis G
通讯作者：
Kassiotis G
影响因子：
64.5
作者：
Gonzalez-Figueroa, Paula;Roco, Jonathan A.;Vinuesa, Carola G.
通讯作者：
Vinuesa, Carola G.
影响因子：
9.8
作者：
Okada T;Miller MJ;Parker I;Krummel MF;Neighbors M;Hartley SB;O'Garra A;Cahalan MD;Cyster JG
通讯作者：
Cyster JG