EFFECT OF SINGLET OXYGEN QUENCHERS ON OXIDATIVE DAMAGE TO LIPOSOMES INITIATED BY PHOTOSENSITIZATION OR BY RADIOFREQUENCY DISCHARGE
EFFECT OF SINGLET OXYGEN QUENCHERS ON OXIDATIVE DAMAGE TO LIPOSOMES INITIATED BY PHOTOSENSITIZATION OR BY RADIOFREQUENCY DISCHARGE
复制标题
单线态氧猝灭剂对光敏化或射频放电引发的脂质体氧化损伤的影响
DOI：
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发表时间：
1974
影响因子：
3.3
通讯作者：
D. C. Clagett
中科院分区：
文献类型：
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作者：
S. Anderson;N. Krinsky;M. Stone;D. C. Clagett
摘要-脂质模型膜系统，脂质体，可被甲苯胺蓝O敏化的光氧化和射频放电产生的单线态氧氧化。氧化之后可能出现脂质过氧化物、丙二醛形成，并最终导致脂质体裂解。在使用β-胡萝卜素或DABCO的两种系统中均观察到氧化抑制。这些意见是一致的，认为II型（单线态氧）反应参与了这个光动力系统。
Abstract—Lipid model membrane systems, liposomes, may be oxidized by both toluidine blue Osensitized photo‐oxidation and radiofrequency‐discharge‐generated singiet oxygen. Oxidation can be followed by the appearance of lipid peroxides, malondialdehyde formation, and ultimately by the lysis of the liposomes. Inhibition of oxidation is observed in both systems using either β‐carotene or DABCO. These observations are consistent with the view that type II (singlet oxygen) reactions are involved in this photodynamic system.