Trichormamide C Structural Confirmation through Total Synthesis and Extension to Analogs
Trichormamide C Structural Confirmation through Total Synthesis and Extension to Analogs
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DOI：
10.1021/acs.orglett.9b04064
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发表时间：
2020-01-03
期刊：
影响因子：
5.2
通讯作者：
Inguimbert, Nicolas
中科院分区：
文献类型：
--
作者：
Darcel, Laurine;Djibo, Mahamadou;Inguimbert, Nicolas
对海洋天然物质作为潜在新药的兴趣日益增长，使得全合成成为结构确认的真实的资产。Trichormamide C（1），一种从蓝藻颤藻属分离的环状脂肽，其特征在于序列中存在非蛋白质氨基酸。通过实施灵活的合成进行三色酰胺C的结构确认，得到两种新的类似物（3和4）。
The growing interest in marine natural substances as potential new drugs has made total synthesis a real asset for structure confirmation. Trichormamide C (1), a cyclic lipopeptide isolated from the cyanobacteria Oscillatoria sp., is characterized by the presence of nonproteinogenic amino acids in the sequence. Trichormamide C structural confirmation was carried out through the implementation of a flexible synthesis resulting in two new analogs (3 and 4).