High mobility group protein HMGA1 expression in breast cancer reveals a positive correlation with tumour grade
High mobility group protein HMGA1 expression in breast cancer reveals a positive correlation with tumour grade
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DOI：
10.14670/hh-18.999
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发表时间：
2003-10-01
影响因子：
2
通讯作者：
Bullerdiek, J
中科院分区：
文献类型：
--
作者：
Flohr, AM;Rogalla, P;Bullerdiek, J
HMGA 蛋白（高迁移率族蛋白 A）家族的成员通过弯曲 DNA 充当染色质结构的主开关，从而调节许多靶基因的转录因子复合物的形成。因此，HMGA蛋白已被证明与多种良性和恶性肿瘤的发生和/或进展相关。尽管如此，迄今为止发表的HMGA1表达研究尚未包括原发性乳腺癌样本。在这项研究中，我们通过免疫组织化学研究了一系列 170 个乳腺癌样本中的 HMGA1 表达模式。我们发现肿瘤之间 HMGA1 表达存在很大差异。根据免疫反应评分 (IRS)，14.1% 的肿瘤样本评分为 IRS 8-12（HMGA1 强阳性），24.7% 评分为 IRS 4-6（中度阳性），25.3% 评分为 IRS 1-3（弱阳性），35.9% 根本没有表现出阳性。除浸润性乳头状癌和筛状癌外，在分析的所有组织学类型的乳腺癌中都可以检测到免疫反应。统计分析显示肿瘤分级与 HMGA1 表达之间存在很强的相关性（rs = 0.3516，p < 0.0001）。因此，HMGA1表达水平可以被认为是乳腺癌的潜在预后标志物。
Members of the HMGA protein (high mobility group protein A) family act as master switches of the chromatin structure by bending DNA and thus modulating the formation of transcription factor complexes of a number of target genes. Accordingly, HMGA proteins have been shown to be associated with the development and/or progression of a variety of benign and malignant tumours. Nevertheless, the HMGA1 expression studies published so far have not included primary breast cancer samples. In this study we have investigated the HMGA1 expression patterns in a series of 170 breast cancer samples by immunohistochemistry. We have found a strong variation in HMGA1 expression between the tumours. Based on an immunoreactive score (IRS) 14.1% of the tumour samples were scored to IRS 8-12 (strong positivity for HMGA1), 24.7% were scored to IRS 4-6 (moderate positivity), 25.3% were scored to IRS 1-3 (weak positivity), and 35.9% showed no positivity at all. Immunoreaction could be detected in all histological types of breast cancers analysed with the exception of invasive papillary and cribriform carcinoma. Statistical analysis revealed a strong correlation between tumour grade and HMGA1 expression (rs = 0.3516, p < 0.0001). Thus, the HMGA1 expression level can be considered a potential prognostic marker for breast cancer.