Seizures Are Associated with Blood-Brain Barrier Disruption in a Piglet Model of Neonatal Hypoxic-Ischaemic Encephalopathy
Seizures Are Associated with Blood-Brain Barrier Disruption in a Piglet Model of Neonatal Hypoxic-Ischaemic Encephalopathy
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DOI：
10.1159/000499365
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发表时间：
2019-01-01
影响因子：
2.9
通讯作者：
Bjorkman, Stella Tracey
中科院分区：
文献类型：
--
作者：
Goasdoue, Kate;Chand, Kirat Kishore;Bjorkman, Stella Tracey
癫痫发作在新生儿时期是最常见的症状中枢神经系统（CNS）功能障碍和最常见的原因是缺氧缺血性脑病（HIE）。癫痫发作与不良的长期预后和神经病理增加有关。血脑屏障（BBB）破坏和炎症可能导致癫痫发作和神经病理增加，但在新生儿HIE中尚不完全清楚。本研究旨在探讨癫痫发作对新生儿缺氧缺血性损伤（HI）临床前模型血脑屏障完整性的影响。小猪(年龄:
Seizures in the neonatal period are most often symptomatic of central nervous system (CNS) dysfunction and the most common cause is hypoxic-ischaemic encephalopathy (HIE). Seizures are associated with poor long-term outcomes and increased neuropathology. Blood-brain barrier (BBB) disruption and inflammation may contribute to seizures and increased neuropathology but are incompletely understood in neonatal HIE. The aim of this study was to investigate the impact of seizures on BBB integrity in a preclinical model of neonatal hypoxic-ischaemic (HI) injury. Piglets (age: