Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome.
Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome.
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DOI：
10.1007/s10803-015-2694-0
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发表时间：
2016-04
影响因子：
3.9
通讯作者：
Schaaf CP
中科院分区：
文献类型：
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作者：
Crutcher E;Ali M;Harrison J;Sovago J;Gomez-Mancilla B;Schaaf CP
15q13.3微缺失综合征导致一系列认知障碍，包括智力残疾和自闭症。我们的目的是确定是否任何或所有三个认知测试（KiTAP，CogState和Stanford-Binet）适合评估受影响个体的认知功能。这三个测试管理10个人与15q13.3微缺失综合征（14-18岁），并分析结果，以确定使用的可行性，改进的潜力，和内部的一致性。已确定KiTAP、CogState和Stanford-Binet是15q13.3微缺失患者认知功能的有效测试。因此，这些测试可以被考虑用作未来临床试验的客观结果指标，评估药物治疗期间认知功能的变化。
15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive tests (the KiTAP, CogState, and Stanford-Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford-Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.