Sympathetic nervous system influences on the kidney. Role in hypertension.
Sympathetic nervous system influences on the kidney. Role in hypertension.
复制标题
交感神经系统对肾脏有影响。
DOI：
10.1093/ajh/2.3.119s
复制
发表时间：
1989
影响因子：
3.2
通讯作者：
DiBona,GF
中科院分区：
文献类型：
--
作者：
DiBona,GF
传出肾交感神经活动（ERSNA）在人类原发性高血压以及动物实验性高血压中升高。此外，双侧完全肾脏去神经支配延迟了动物中几种不同形式的实验性高血压的发展和/或减弱了高血压的程度。已知传出肾交感神经活动对肾血流量和肾小球滤过率、肾小管钠和水重吸收以及肾素分泌率具有剂量依赖性作用，其能够单独或组合地促进高血压状态的发展、维持和恶化。在已知影响ERSNA的中枢神经系统整合调节的许多因素中，两个环境因素，膳食钠摄入量和环境应激，能够显著相互作用。由此导致的ERSNA增加和随后的肾功能改变可参与高血压过程。这一点在存在导致高血压发展的潜在遗传易感性的情况下尤其明显。因此，环境和遗传影响之间的相互作用可以产生对肾功能的交感神经控制的改变，这在高血压中起重要作用。美国高血压杂志1989;2：119 S-124 S
Efferent renal sympathetic nerve activity (ERSNA) is elevated in human essential hypertension as well as several forms of experimental hypertension in animals. In addition, bilateral complete renal denervation delays the development and/or attenuates the magnitude of the hypertension in several different forms of experimental hypertension in animals. Efferent renal sympathetic nerve activity is known to have dose-dependent effects on renal blood flow and glomerular filtration rate, renal tubular sodium and water reabsorption, and renin secretion rate that are capable of contributing, singly or in combination, to the development, maintenance, and exacerbation of the hypertensive state. Of the many factors known to influence the central nervous system integrative regulation of ERSNA, two environmental factors, dietary sodium intake and environmental stress, are capable of significant interaction. This resultant increase in ERSNA and subsequent renal functional alterations can participate in the hypertensive process. This is especially evident in the presence of an underlying genetic predisposition to the development of hypertension. Thus, interactions between environmental and genetic influences can produce alterations in the sympathetic neural control of renal function that play an important role in hypertension. Am J Hypertens 1989;2:119S-124S