Eye-centered, head-centered, and complex coding of visual and auditory targets in the intraparietal sulcus
Eye-centered, head-centered, and complex coding of visual and auditory targets in the intraparietal sulcus
复制标题
DOI：
10.1152/jn.00021.2005
复制
发表时间：
2005-10-01
影响因子：
2.5
通讯作者：
Groh, JM
中科院分区：
文献类型：
--
作者：
Mullette-Gillman, OA;Cohen, YE;Groh, JM
视觉和听觉事件的整合被认为需要在一个共同的参考框架中对视觉和听觉空间进行联合表示。我们研究了外侧和内侧顶叶内区（LIP， MIP）的视觉和听觉空间编码作为这种表征的候选。当两只猴子从三个不同的眼睛位置对一排视觉和听觉目标进行扫视时，我们记录了它们的上颌部和下颌部275个神经元的活动。我们发现这些神经元中有45%受视觉目标的位置调节，19%受听觉目标的位置调节，9%受视觉和听觉目标的位置调节。视觉和听觉感受野的参照系在以眼睛为中心和以头部为中心的参照系之间的连续体上分布，大约10%的听觉神经元和33%的视觉神经元的感受野与以眼睛为中心的参照系更为一致，23%和18%的神经元的感受野与以头部为中心的参照系更为一致，而不是以眼睛为中心的参照系。留下很大一部分视觉和听觉反应模式与以头和眼睛为中心的参照系不一致。结果与我们之前在下丘和核心听觉皮层中发现的听觉刺激的参考框架相似。单个神经元的视觉和听觉感受野之间的对应关系很弱。然而，视觉和听觉反应之间的相关性非常好，即使权重仅基于视觉反应进行拟合，我们也可以构建一个简单的单层网络，通过我们样本中神经元的活动来计算目标位置。我们将这些结果解释为，尽管LIP和MIP区域的空间表征不容易在参考框架的传统概念框架内描述，但它们以类似的方式处理视觉和听觉空间信息。
The integration of visual and auditory events is thought to require a joint representation of visual and auditory space in a common reference frame. We investigated the coding of visual and auditory space in the lateral and medial intraparietal areas ( LIP, MIP) as a candidate for such a representation. We recorded the activity of 275 neurons in LIP and MIP of two monkeys while they performed saccades to a row of visual and auditory targets from three different eye positions. We found 45% of these neurons to be modulated by the locations of visual targets, 19% by auditory targets, and 9% by both visual and auditory targets. The reference frame for both visual and auditory receptive fields ranged along a continuum between eye- and head- centered reference frames with similar to 10% of auditory and 33% of visual neurons having receptive fields that were more consistent with an eye- than a head- centered frame of reference and 23 and 18% having receptive fields that were more consistent with a head-than an eye- centered frame of reference, leaving a large fraction of both visual and auditory response patterns inconsistent with both head- and eye- centered reference frames. The results were similar to the reference frame we have previously found for auditory stimuli in the inferior colliculus and core auditory cortex. The correspondence between the visual and auditory receptive fields of individual neurons was weak. Nevertheless, the visual and auditory responses were sufficiently well correlated that a simple one- layer network constructed to calculate target location from the activity of the neurons in our sample performed successfully for auditory targets even though the weights were fit based only on the visual responses. We interpret these results as suggesting that although the representations of space in areas LIP and MIP are not easily described within the conventional conceptual framework of reference frames, they nevertheless process visual and auditory spatial information in a similar fashion.