Reversal of liver fibrosis.
Reversal of liver fibrosis.
复制标题
逆转肝纤维化。
DOI：
10.4103/1319-3767.45072
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Pinzani M
中科院分区：
文献类型：
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作者：
Ismail MH;Pinzani M
肝纤维化是一种与肝细胞外基质沉积增加和改变相关的瘢痕形成过程。它是由各种刺激引起的，如果纤维化继续不受抵抗，它将进展为肝硬化，这在世界范围内构成了一个重大的健康问题。在细胞和分子水平上，这一渐进过程的特征是肝星状细胞的细胞激活和转化生长因子-β及其下游细胞介体的异常活性。肝活检一直是评估肝纤维化的参考检查，但由于其局限性，肝纤维化的非侵入性标志物被开发出来。过去认为肝纤维化或肝硬化是不可逆的，但对肝纤维化分子发病机制的研究进展表明，肝细胞恢复是可能的。目前，没有可接受的治疗策略存在，除了去除纤维化刺激，以治疗这种潜在的破坏性疾病。
Hepatic fibrosis is a scarring process associated with an increased and altered deposition of extracellular matrix in the liver. It is caused by a variety of stimuli and if fibrosis continues unopposed, it would progress to cirrhosis which poses a significant health problem worldwide. At the cellular and molecular level, this progressive process is characterized by cellular activation of hepatic stellate cells and aberrant activity of transforming growth factor-β with its downstream cellular mediators. Liver biopsy has been the reference test for assessment of hepatic fibrosis, but because of its limitations, noninvasive markers of liver fibrosis were developed. Liver fibrosis or cirrhosis was considered irreversible in the past but progress of research on the molecular pathogenesis of liver fibrosis has shown that hepatic cellular recovery is possible. Currently, no acceptable therapeutic strategies exist, other than removal of the fibrogenic stimulus, to treat this potentially devastating disease.