Site-specific properties of pericardial and epicardial adipose tissue: the effects of insulin and high-fat feeding on lipogenesis and the incorporation of fatty acids in vitro.
Site-specific properties of pericardial and epicardial adipose tissue: the effects of insulin and high-fat feeding on lipogenesis and the incorporation of fatty acids in vitro.
复制标题
心包和心外膜脂肪组织的位点特异性：胰岛素和高脂肪喂养对体外脂肪生成和脂肪酸掺入的影响。
DOI：
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发表时间：
1990
影响因子：
4.9
通讯作者：
C. Pond
中科院分区：
文献类型：
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作者：
Jacqueline M. Marchington;C. Pond
在豚鼠心脏的心包和心外膜脂肪组织以及肝脏和两个较大的脂肪库中研究了体外脂肪生成和脂肪酸掺入率。心脏贮库的脂肪生成和脂肪酸掺入率均高于研究的任何其他组织。与检查的所有其他组织相比，心脏贮库中的脂肪酸掺入率不受胰岛素（0.1 U/ml）的影响，并且心脏贮库中的胰岛素增加了脂肪生成，但在其他脂肪贮库或肝脏中没有。高脂喂养增加了体外脂肪酸掺入率在所有组织检查，但脂肪生成率不变，除了在肾周脂肪组织（减少）和肝脏（增加）。这些数据与心外膜脂肪组织可能作为心肌的局部能量储存并对冠状循环中游离脂肪酸水平升高具有保护作用的假设一致。
Lipogenesis and the rate of fatty acid incorporation in vitro were studied in the pericardial and epicardial adipose tissue of the guinea-pig heart and in the liver and two larger adipose depots. Both lipogenesis and the rate of fatty acid incorporation were higher in the cardiac depots than in any of the other tissues studied. The rate of fatty acid incorporation were unaffected by insulin (0.1 U/ml) in the cardiac depots in contrast to all other tissues examined, and lipogenesis was increased by insulin in the cardiac depots, but not in the other adipose depots or liver. High-fat feeding increased the rate of fatty acid incorporation in vitro in all tissues examined, but the rates of lipogenesis were unchanged except in perirenal adipose tissue (decrease) and liver (increase). The data are consistent with the hypothesis that epicardial adipose tissue may act as a local energy store for cardiac muscle and have a protective role against elevated levels of free fatty acid in the coronary circulation.