IFT-Cargo Interactions and Protein Transport in Cilia.
IFT-Cargo Interactions and Protein Transport in Cilia.
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DOI：
10.1016/j.tibs.2015.09.003
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发表时间：
2015-12
影响因子：
13.8
通讯作者：
Lechtreck KF
中科院分区：
文献类型：
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作者：
Lechtreck KF
纤毛和鞭毛的运动和感觉功能对人类健康是不可或缺的。纤毛的组装需要专门的蛋白质穿梭，鞭毛内运输(IFT)，沿着纤毛微管的多兆吨蛋白质阵列的双向运动。IFT作为一种蛋白质载体，将数百种不同的蛋白质输送到正在生长的纤毛中。基于IFT的蛋白质进出口在完全生长的纤毛中继续存在，是纤毛维持和传感所必需的。大的纤毛构筑块可能依赖IFT通过过渡区，该过渡区起到纤毛门的作用。更小的、自由扩散的蛋白质，如微管蛋白，依赖于IFT被浓缩或从纤毛中去除。最近的工作为IFT如何与其货物互动以及如何监管运输提供了见解。
The motile and sensory functions of cilia and flagella are indispensable for human health. Cilia assembly requires a dedicated protein shuttle, intraflagellar transport (IFT), a bidirectional motility of multi-megadalton protein arrays along ciliary microtubules. IFT functions as a protein carrier delivering hundreds of distinct proteins into growing cilia. IFT-based protein import and export continue in fully grown cilia and are required for ciliary maintenance and sensing. Large ciliary building blocks might depend on IFT to move through the transition zone, which functions as a ciliary gate. Smaller, freely diffusing proteins such as tubulin depend on IFT to be concentrated or removed from cilia. Recent work provides insights into how IFT interacts with its cargoes and how the transport is regulated.