Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association
Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association
复制标题
SUMO1 假基因 3 (SUMO1P3) 在胃癌中的上调及其临床关联
DOI：
10.1007/s12032-013-0709-2
复制
发表时间：
2013-12-01
期刊：
影响因子：
3.4
通讯作者：
Guo, Junming
中科院分区：
文献类型：
--
作者：
Mei, Danyi;Song, Haojun;Guo, Junming
长链非编码RNA（lncRNA）在肿瘤的发生、发展过程中起着重要作用。假基因表达的lncRNA是lncRNA家族的主要类型之一。然而，它们与癌症的关系在很大程度上是未知的。在这项研究中，我们专注于小泛素样修饰物（SUMO）1假基因3，SUMO 1 P3。收集96例胃癌患者的癌组织及癌旁组织。采用逆转录-聚合酶链反应（RT-PCR）检测SUMO 1 P3的表达水平。进一步分析SUMO 1 P3在胃癌组织中的表达水平与胃癌患者临床病理特征的关系。建立了胃癌与胃良性疾病的受试者工作特征曲线。结果显示，SUMO 1 P3在胃癌组织中的表达明显高于癌旁组织（P< 0.01）。其表达水平与肿瘤大小（p= 0.003）、分化（p= 0.002）、淋巴结转移（p= 0.001）和侵袭（p= 0.039）显著相关。SUMO 1 P3的ROC曲线下面积达0.666。这些结果首次表明，假基因表达的lncRNA SUMO 1 P3可能是胃癌诊断的潜在生物标志物。
Long noncoding RNAs (lncRNAs) play crucial roles during cancer occurrence and progression. The pseudogene-expressed lncRNA is one major type of lncRNA family. However, their association with cancers is largely unknown. In this study, we focused on small ubiquitin-like modifier (SUMO) 1 pseudogene 3, SUMO1P3. Gastric cancer tissues and adjacent nontumor tissues were collected from 96 patients with gastric cancer. The SUMO1P3 levels were detected by quantitative reverse transcription-polymerase chain reaction. Then, the association between the level of SUMO1P3 in gastric cancer tissues and the clinicopathological features of patients with gastric cancer was further analyzed. A receiver operating characteristic curve was constructed for differentiating patients with gastric cancer from patients with benign gastric diseases. The results showed that SUMO1P3 was significantly up-regulated in gastric cancer tissues compared with paired-adjacent nontumorous tissues (p< 0.01). Its expression level was significantly correlated with tumor size (p= 0.003), differentiation (p= 0.002), lymphatic metastasis (p= 0.001), and invasion (p= 0.039). The area under the ROC curve of SUMO1P3 was up to 0.666. These results indicated, for the first time, that pseudogene-expressed lncRNA SUMO1P3 may be a potential biomarker in the diagnosis of gastric cancer.