Sleep Quality and Health-Related Quality of Life in Idiopathic Pulmonary Fibrosis
Sleep Quality and Health-Related Quality of Life in Idiopathic Pulmonary Fibrosis
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DOI：
10.1378/chest.08-0173
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发表时间：
2008-10-01
期刊：
影响因子：
9.6
通讯作者：
Danoff, Sonye K.
中科院分区：
文献类型：
--
作者：
Krishnan, Vidya;McCormack, Meredith C.;Danoff, Sonye K.
背景：特发性肺纤维化（IPF）是一种导致肺实质不可逆瘢痕形成的进行性疾病。虽然疲劳是一个突出的症状，IPF患者的睡眠质量知之甚少，IPF.Methods：在这一横断面研究的41例IPF患者从一个前瞻性设计的队列，我们确定的匹兹堡睡眠质量指数（PSQI）和埃普沃思嗜睡量表的睡眠质量。健康状况，基线人口统计学，和生理参数也assessed.Results：IPF患者报告极差的睡眠质量和高频率的白天嗜睡，这与正常对照人群显着不同。此外，睡眠质量差与体重指数、年龄、性别或肺功能无关。这一人群在身体机能和活力等多个领域的健康状况也极差。睡眠质量差（由全球PSQI）与几个领域的生活质量（QOL）下降显著相关，包括身体功能的作用（r =-0.58，p = 0.001），活力（r =-0.43，p = 0.015），以及情绪的作用（r =-0.40，p = 0.023）。睡眠质量差在IPF患者中极为常见，传统上与睡眠呼吸障碍相关的变量无法预测。此外，睡眠质量差与QOL差有关。这些结果表明，系统评价IPF睡眠质量差的原因是值得的。（CHEST 2008，134：693-698）
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive disorder resulting in irreversible scarring of the lung parenchyma. Although fatigue is a prominent symptom for patients with IPF, little is known about sleep quality in patients with IPF.Methods: In this cross-sectional study of 41 patients with IPF from a prospectively designed cohort, we ascertained sleep quality by means of the Pittsburgh sleep quality index (PSQI) and the Epworth sleepiness scale. Health status, baseline demographics, and physiologic parameters were also assessed.Results: Patients with IPF reported extremely poor sleep quality and high frequency of daytime sleepiness, which differs significantly from normal control populations. Further, poor sleep quality was not associated with body mass index, age, gender, or lung function. This population also demonstrated extremely poor health status in a number of domains, including physical function and vitality. Poor sleep quality (by the global PSQI) was significantly associated with decreased quality of life (QOL) in several domains, including role of physical function (r = - 0.58, p = 0.001), vitality (r = - 0.43, p = 0.015), and role of emotions (r = - 0.40, p = 0.023).Conclusions: Poor sleep quality is extremely common in patients with IPF and is not predicted by variables traditionally associated with sleep-disordered breathing. Further, poor sleep quality is associated with poor QOL. These findings suggest that systematic evaluation of the cause of poor sleep quality in IPF is merited. (CHEST 2008, 134:693-698)