ORIGIN OF URINARY DIMETHYLAMINE
ORIGIN OF URINARY DIMETHYLAMINE
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DOI：
10.1016/0304-4165(65)90048-6
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发表时间：
1965-01-01
期刊：
影响因子：
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通讯作者：
SIMENHOF.ML
中科院分区：
文献类型：
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作者：
ASATOOR, AM;SIMENHOF.ML
证据表明，二甲胺是来自，部分，从摄入的胆碱和卵磷脂。由胆碱形成二甲胺依赖于肠道中的细菌作用。用三甲基胺进行的实验结果表明，三甲基胺是胆碱转化为二甲胺的中间体。用新霉素对肠道进行灭菌可使二甲胺排泄减少约20%，这表明胺的主要部分来自内源性来源。二甲基甘氨酸，二甲基乙醇胺，甜菜碱和DL-肉毒碱，注入大鼠，二甲胺排泄量没有显着变化。[C14]将甲胺和L-[Me-C14]蛋氨酸分别注射到大鼠体内，在两种情况下，放射性均掺入二甲胺中。因此，甲胺是二甲胺的重要内源性来源，而甲硫氨酸充当甲基供体。
Evidence is presented to show that dimethylamine is derived, partly, from ingested choline and lecithin. The formation of dimethylamine from choline is dependent on bacterial action in the intestine. Results of experiments with trimethylamine suggest that trimethyla-mine is an intermediate in the conversion of choline to dimethylamine. Sterilization of the gut with neomycin reduced dimethylamine excretion by about 20%, suggesting that the major portion of the amine is derived from endogenous sources. Dimethylglycine, dimethylethano-lamine, betaine and DL-carnitine, injected into rats, caused no significant change in dimethylamine excretion. [C14] Methylamine and L-[Me-C14] methionine were separately injected into rats, and in both instances radioactivity was incorporated into dimethylamine. Methylamine is, therefore, an important endogenous source of dimethylamine and methionine serves as the methyl donor.