Changes in serotype distribution of Haemophilus influenzae meningitis isolates identified through laboratory-based surveillance following routine childhood vaccination against H. influenzae type b in Brazil
Changes in serotype distribution of Haemophilus influenzae meningitis isolates identified through laboratory-based surveillance following routine childhood vaccination against H. influenzae type b in Brazil
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DOI：
10.1016/j.vaccine.2011.09.053
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发表时间：
2011-11-08
期刊：
影响因子：
5.5
通讯作者：
Brandileone, Maria Cristina de C.
中科院分区：
文献类型：
--
作者：
Zanella, Rosemeire C.;Bokermann, Sergio;Brandileone, Maria Cristina de C.
1999年巴西儿童常规接种B型流感嗜血杆菌（HiB）疫苗后，被动实验室监测报告非B血清型和无法分型的H.流感病毒（NTHi）从脑膜炎病例。为了表征这种增加，我们分析了3910 H的数据。从1990年至2008年送往国家参考实验室进行血清分型的脑膜炎病例的脑脊液或血液中分离出的流感病毒。Hib占H. 1990-1999年期间收到的流感脑膜炎分离株与2000-2008年期间的59%相比，而非b血清型从1%增加到19%，NTHi从2%增加到22%。在两个时期内收到的流感病毒分离株。非b血清型和NTHi的比例高于Hib。从血液中分离而不是从脑脊液中分离。估计的H.在2000-2008年期间，圣保罗州的流感脑膜炎仍低于每百万人口1例，尽管NTHi脑膜炎的年发病率（平均每10万人口0.03例）在几个年龄组中有所增加。监测H.引入Hib结合疫苗后的流感可能导致非b型和不可分型H的数量增加。国家参考实验室收到的流感脑膜炎分离株。(C)2011爱思唯尔有限公司版权所有。
Following routine childhood vaccination against Haemophilus influenzae type b (Hib) disease in Brazil in 1999, passive laboratory surveillance reported increasing numbers of non-b serotypes and nontypeable H. influenzae (NTHi) from meningitis cases. To characterize this increase, we analyzed data on 3910 H. influenzae isolated from cerebrospinal fluid or blood from meningitis cases that were sent to the national reference laboratory for serotyping from 1990 to 2008. Hib accounted for 98% of H. influenzae meningitis isolates received during 1990-1999 versus 59% during 2000-2008, while non-b serotypes increased from 1% to 19% and NTHi increased from 2% to 22% of H. influenzae isolates received during the two periods. Higher proportions of non-b serotypes and NTHi than Hib were. isolated from blood rather than cerebrospinal fluid. Estimated incidence rates for H. influenzae meningitis for Sao Paulo state remained below 1 case per million population during 2000-2008, although annual incidence of NTHi meningitis (mean, 0.03 cases per 100,000 population) increased in several age groups. Changes in surveillance for H. influenzae following introduction of Hib conjugate vaccine likely contributed to increased numbers of non-b and nontypeable H. influenzae meningitis isolates received at the national reference laboratory. (C) 2011 Elsevier Ltd. All rights reserved.