Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors.
Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors.
复制标题
人 β-防御素 1 和 β-防御素 3（小鼠直系同源物 mBD14）在选定的黑皮质素受体上发挥完全内源性激动剂的作用。
DOI：
10.1021/acs.jmedchem.8b00251
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发表时间：
2018
影响因子：
7.3
通讯作者：
Haskell-Lue
中科院分区：
文献类型：
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作者：
Ericson,MarkD;Singh,Anamika;Tala,SrinivasaR;Haslach,EricaM;Dirain,MarvinLS;Schaub,JayW;Flores,Viktor;Eick,Natalie;Lensing,CodyJ;Freeman,KatieT;Smeester,BrandenA;Adank,DanielleN;Wilber,StaceyL;Speth,Robert;Haskell-Lue
β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human BD3 and mouse BD3 are full micromolar agonists at the MCRs. Furthermore, mouse β-defensin 1 (BD1) and human BD1 are also MCR micromolar agonists. This work identifies BD1 as an endogenous MCR ligand and clarifies the controversial role of BD3 as a micromolar agonist.
