Femorotibial Cartilage Morphology: Reproducibility of Different Metrics and Femoral Regions, and Sensitivity to Change in Disease
Femorotibial Cartilage Morphology: Reproducibility of Different Metrics and Femoral Regions, and Sensitivity to Change in Disease
复制标题
股胫软骨形态：不同指标和股骨区域的再现性以及对疾病变化的敏感性
作者：
M. Hudelmaier;W. Wirth;B. Wehr;Virginia B. Kraus;B. Wyman;M. P. H. Graverand;Felix Eckstein
本研究旨在表征基于磁共振成像的软骨形态指标和股骨感兴趣区域（ROI）变化的可重复性和敏感性，以便在软骨形态的纵向研究中提供更好的结果指标。在33例有和无骨关节炎（OA）影像学体征的受试者中获得了3特斯拉（T）的重测采集（再现性研究），在28例有晚期OA影像学体征的受试者中获得了基线和2年随访采集（敏感性研究）。在胫骨和两个不同的解剖股骨ROI中分割肱骨，一个“长”ROI从股骨髁间窝延伸60%到髁后端，一个“短”ROI延伸到髁间骨桥。获得不同形态学指标和解剖区域的变异系数（再现性研究）和标准化响应均值（SRM，敏感性研究）。长ROI的软骨下骨面积比短ROI的大20%，并且变化较小;软骨形态指标在长ROI中通常更具重现性。与软骨体积（SRM高达-0.44）、软骨区域上的软骨厚度（ThCcAB; SRM高达-0.48）或最大软骨厚度（ThCtAB; SRM高达-0.35）相比，标准化软骨体积（VCtAB）和平均软骨厚度（在整个软骨下骨区域上; ThCtAB.Me）往往更具可重复性，对变化更敏感（SRM高达-0.62）。长股骨软骨ROI比短股骨软骨ROI提供更多的可重复测量。VCtAB和ThCtAB.Me可能是关节软骨适应或OA纵向研究中的优选指标。
This study was designed to characterize the reproducibility and sensitivity to change of magnetic resonance imaging-based cartilage morphology metrics and femoral regions of interest (ROIs), in order to provide preferable outcome measures in longitudinal studies of cartilage morphology. Test-retest acquisitions were obtained at 3 tesla (T) in 33 subjects with and without radiographic signs of osteoarthritis (OA) (reproducibility study) as well as baseline and 2-year follow-up acquisitions in 28 subjects with radiographic signs of advanced OA (sensitivity study). Cartilage was segmented in the tibia and two distinct anatomical femoral ROIs, a ‘long’ ROI extending 60% from the trochlear notch to the posterior end of the condyles, and a ‘short’ ROI extending to the intercondylar bone bridge. Coefficients of variation (reproducibility study) and standardized response means (SRMs, sensitivity study) were obtained for different morphology metrics and anatomical regions. The subchondral bone area of the long ROI was 20% greater and less variable than that of the short ROI; cartilage morphology metrics were generally more reproducible in the long ROI. Normalized cartilage volume (VCtAB) and mean cartilage thickness (over the entire subchondral bone area; ThCtAB.Me) tended to be more reproducible and more sensitive to change (SRM up to –0.62) than cartilage volume (SRM up to –0.44), cartilage thickness over the cartilaginous area (ThCcAB; SRM up to –0.48) or maximum cartilage thickness (ThCtAB; SRM up to –0.35). The long femoral cartilage ROI provided more reproducible measurements than the short one. VCtAB and ThCtAB.Me may be preferable metrics in longitudinal studies of articular cartilage adaptation or OA.
影响因子：
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作者：
Sharma, Leena;Eckstein, Felix;Dunlop, Dorothy
通讯作者：
Dunlop, Dorothy