Plasma omega-3 fatty acids and incident diabetes in older adults
Plasma omega-3 fatty acids and incident diabetes in older adults
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DOI：
10.3945/ajcn.111.013334
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发表时间：
2011-08-01
影响因子：
7.1
通讯作者：
Mozaffarian, Dariush
中科院分区：
文献类型：
--
作者：
Djousse, Luc;Biggs, Mary L.;Mozaffarian, Dariush
背景资料：虽然通过食物频率问卷估计的长链ω-3脂肪酸（n-3 FA）消耗量与糖尿病的较高发病率相关，但使用n-3 FA的客观生物标志物的糖尿病风险前瞻性数据有限。目的：我们试图检查血浆磷脂n-3 FA与糖尿病发病率之间的关系。设计：我们前瞻性地分析了来自心血管健康研究（1992 - 2007）的3088名老年男性和女性（平均年龄：75岁）的数据。采用气相色谱法测定血浆磷脂n-3脂肪酸，并通过使用降糖药和血糖信息确定糖尿病发病率。我们使用考克斯比例风险模型来估计多变量调整的相对risk.Results：在一个中位数为10.6年的后续，204例糖尿病新发病例发生。在控制年龄、性别、种族、诊所、体重指数、饮酒、吸烟、体力活动、低密度脂蛋白胆固醇和亚油酸的多变量模型中，糖尿病的相对危险度（95% CI）为1.0（参考），0.96（0.65，1.43），1.03（0.69，1.54）和0.64（0.41，1.01）跨磷脂二十碳五烯酸和二十二碳六烯酸的连续四分位数（趋势P = 0.05）。磷脂α-亚麻酸（ALA）的相应相对风险（95% CI）为1.0（参考），0.93（0.65，1.34），0.99（0.68，1.44）和0.57（0.36，0.90）（趋势P = 0.03）。结论：在使用客观生物标志物的情况下，长链n-3 FA和ALA与糖尿病的高发病率无关。两种脂肪酸浓度最高的个体患糖尿病的风险较低。美国临床营养杂志2011; 94：527 - 33。
Background: Although long-chain omega-3 fatty acid (n-3 FA) consumption estimated via food-frequency questionnaires has been associated with a higher incidence of diabetes, limited prospective data on diabetes risk are available that use objective biomarkers of n-3 FAs.Objective: We sought to examine the relation between plasma phospholipid n-3 FAs and incident diabetes.Design: We prospectively analyzed data in 3088 older men and women (mean age: 75 y) from the Cardiovascular Health Study (1992-2007). Plasma phospholipid n-3 FAs were measured by using gas chromatography, and incident diabetes was ascertained by using information on hypoglycemic agents and serum glucose. We used Cox proportional hazards models to estimate multivariable-adjusted relative risks.Results: During a median follow-up of 10.6 y, 204 new cases of diabetes occurred. In a multivariable model that controlled for age, sex, race, clinic site, body mass index, alcohol intake, smoking, physical activity, LDL cholesterol, and linoleic acid, relative risks (95% CIs) for diabetes were 1.0 (reference), 0.96 (0.65, 1.43), 1.03 (0.69, 1.54), and 0.64 (0.41, 1.01) across consecutive quartiles of phospholipid eicosapentaenoic acid and docosahexaenoic acid (P for trend = 0.05). Corresponding relative risks (95% CIs) for phospholipid alpha-linolenic acid (ALA) were 1.0 (reference), 0.93 (0.65, 1.34), 0.99 (0.68, 1.44), and 0.57 (0.36, 0.90) (P for trend = 0.03).Conclusions: With the use of objective biomarkers, long-chain n-3 FAs and ALA were not associated with a higher incidence of diabetes. Individuals with the highest concentrations of both types of FAs had lower risk of diabetes. Am J Clin Nutr 2011;94:527-33.