Do Women who Receive a Negative BRCA1/2 Risk Result Understand the Implications for Breast Cancer Risk?
Do Women who Receive a Negative BRCA1/2 Risk Result Understand the Implications for Breast Cancer Risk?
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DOI：
10.1159/000503129
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发表时间：
2019-12-01
影响因子：
1.7
通讯作者：
McBride, Colleen M.
中科院分区：
文献类型：
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作者：
Guan, Yue;Condit, Celeste M.;McBride, Colleen M.
背景/目标：国家指南支持使用基于证据的工具来识别那些有遗传性乳腺癌和卵巢癌 (HBOC) 风险的人。这项研究旨在评估女性是否被认为不会增加成为 BRCA 突变携带者的风险； the majority of those screened, recall, understand and accept the implications of these results for breast cancer risk.方法：我们对 HBOC 简短筛查结果呈阴性的女性 (n = 148) 进行了一项在线调查。结果：虽然女性倾向于接受 HBOC 筛查仪的准确性（范围 9-45；平均值 32，SD 5.0），但只有不到一半 (43%) 的女性能够准确回忆起她们的结果。只有 52% 的人了解自己携带突变的风险较低，只有 34% 的人正确了解自己患乳腺癌的风险。与白人相比，非洲裔美国女性回忆（分别为 33% vs. 53%，OR 0.5，p = 0.03）、理解（分别为 42% vs. 63%，OR 0.4，p = 0.02）和接受（平均值分别为 31% vs. 33，beta -2.1，p = 0.02）结果的可能性较小。结论：我们的研究结果表明，携带 BRCA1/2 突变的低风险人群对突变风险和乳腺癌风险之间的区别了解有限。需要基于理论的沟通策略来增进对遗传性癌症低风险影响的理解。
Background/Aims: National guidelines endorse using evidence-based tools to identify those at risk for hereditary breast and ovarian cancer (HBOC). This study aimed to evaluate whether women deemed not to be at increased risk of being a BRCA mutation carrier; the majority of those screened, recall, understand and accept the implications of these results for breast cancer risk. Methods: We conducted an online survey with women (n = 148) who screened negative on a brief HBOC screener. Results: While women tended to accept HBOC screener as accurate (range 9-45; mean 32, SD 5.0), less than half (43%) accurately recalled their result. Only 52% understood that they were at low risk of carrying a mutation, and just 34% correctly understood their breast cancer risk. African American women were less likely to recall (33 vs. 53% respectively, OR 0.5, p = 0.03), understand (42 vs. 63% respectively, OR 0.4, p = 0.02), and accept (mean 31 vs. 33 respectively, beta -2.1, p = 0.02) the result compared to Whites. Conclusions: Our findings show that those at low risk of carrying a BRCA1/2 mutation had limited understanding of the distinction between mutation risk and breast cancer risk. Theory-based communication strategies are needed to increase the understanding of the implications of being at low risk for hereditary cancers.