Intentional weight loss and risk of lymphohematopoietic cancers
Intentional weight loss and risk of lymphohematopoietic cancers
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DOI：
10.1007/s10552-009-9453-5
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发表时间：
2010-02-01
影响因子：
2.3
通讯作者：
LaCroix, Andrea Z.
中科院分区：
文献类型：
--
作者：
De Roos, Anneclaire J.;Ulrich, Cornelia M.;LaCroix, Andrea Z.
我们假设，故意减肥可能与淋巴造血细胞癌的发展，根据观察免疫抑制以下的体重减轻在短期study.At基线的妇女健康倡议观察性研究（1994-1998），参与者报告的信息故意减肥发作在过去的20年。在平均9.9年的随访中，我们估计了81,219名女性过去故意减肥与发生非霍奇金淋巴瘤（NHL）、白血病和多发性骨髓瘤风险之间关系的风险比（HR）和95%置信区间（CI）。NHL的风险与体重减轻的最大量有关（千分之一日元50磅，HR = 1.68，95% CI 1.13-2.50）。NHL风险也因有意减肥的频率而异;女性如果减掉50磅或更多，风险就会增加。（HR = 1.97，95% CI 0.93-4.16;频率的p趋势= 0.09）或20-49磅/份/千日元3次（HR = 1.55，95% CI 1.00-2.40; p趋势= 0.05），但与较少量的体重减轻（10-19磅/千日元3次，HR = 0.78，95% CI 0.46-1.33）无关。这些关联在不同年龄的体重指数调整后仍然存在。我们观察到与多发性骨髓瘤相似程度的非显著相关性，但过去的有意减肥事件与白血病无关，进一步评估有意减肥作为淋巴瘤的可能危险因素可能有助于了解这些癌症的病因。
We hypothesized that intentional weight loss may be associated with development of lymphohematopoietic cancers, based on observations of immune suppression following weight loss in short-term studies.At the baseline of the Women's Health Initiative Observational Study (1994-1998), participants reported information about intentional weight loss episodes in the past 20 years. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) among 81,219 women for associations between past intentional weight loss and risk of developing non-Hodgkin lymphoma (NHL), leukemia, and multiple myeloma during an average 9.9 years of follow-up.The risk of NHL was associated with having lost a large maximum amount of weight (a parts per thousand yen50 pounds, HR = 1.68, 95% CI 1.13-2.50). NHL risk also varied by the frequency of intentional weight loss; women had increased risk if they lost 50 pounds or more a parts per thousand yen3 times (HR = 1.97, 95% CI 0.93-4.16; p trend by frequency = 0.09) or 20-49 pounds a parts per thousand yen3 times (HR = 1.55, 95% CI 1.00-2.40; p trend = 0.05), but there was no risk associated with smaller amounts of weight loss (10-19 pounds a parts per thousand yen3 times, HR = 0.78, 95% CI 0.46-1.33). These associations persisted with adjustment for body mass index at different ages. We observed non-significant associations of similar magnitude for multiple myeloma, but past intentional weight loss episodes were not associated with leukemia.Further assessment of intentional weight loss as a possible risk factor for lymphomas may provide insight into the etiology of these cancers.