Cross-linking and new bone collagen synthesis in immobilized and recovering primate osteoporosis.
Cross-linking and new bone collagen synthesis in immobilized and recovering primate osteoporosis.
复制标题
灵长类骨质疏松症固定和恢复中的交联和新骨胶原合成。
DOI：
10.1016/8756-3282(88)90124-x
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发表时间：
1988
期刊：
影响因子：
4.1
通讯作者：
Mechanic,GL
中科院分区：
文献类型：
--
作者：
Yamauchi,M;Young,DR;Chandler,GS;Mechanic,GL
从不同的时间段的固定（长达7个月）和随后的reamerization（长达40个月）的猴骨（胫骨）的胶原交联的定量测定。结果表明，可还原的交联浓度显着增加，并在7个月的固定期达到峰值，并恢复到40个月后的控制值。主要交联肽的色谱图表明，固定7个月后，I型胶原α1链的残基Hylald-16 cas和Lysald-16 c与α链的残基87 Hyl之间的交联增加。成熟、稳定的交联浓度以及它们的分子位点在整个固定化和reamerization过程中保持恒定。这些结果有力地表明，快速的新骨胶原合成过程中发生的骨质疏松状态，由于固定。随着长期恢复，胶原蛋白合成速率明显恢复到与对照骨相匹配。
Quantification of collagen cross-links of monkey bone (tibia), from various time periods of immobilization (up to 7 months) and their subsequent reambulation (up to 40 months) was determined. Results indicated reducible cross-link concentrations markedly increased and peaked at the seven-month period of immobilization and returned to control values after 40 months of recovery. Chromatographic profiles of the major cross-linked peptides indicated that the increased cross-linking after seven months immobilization occurred between residue Hylald-16cas well as Lysald-16cof the α1 chains and residue 87 Hyl of α chains of type I collagen. Mature, stable cross-link concentrations as well as their molecular loci remained constant throughout immobilization and reambulation. These results strongly suggest that rapid new bone collagen synthesis occurred during the osteoporotic state due to immobilization. With long-term recovery, the rate of collagen synthesis apparently returned to match the control bone.