The Cell as a Decision-Making Unit
The Cell as a Decision-Making Unit
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细胞作为决策单位
DOI：
10.1109/lls.2016.2644648
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
D. Segrè
中科院分区：
文献类型：
--
作者：
L. Castelli;R. Pesenti;D. Segrè
每个活细胞都需要解决一个资源分配问题，其中多个输入（摄取通量）和输出（分泌通量）是生化途径的化学计量和代谢酶调节的结果。量化一个细胞解决这个资源分配问题的效率构成了“细胞经济学”中的一个基本问题。在这封信中，我们提出使用数据包络分析（DEA）来定义多维产量，可以捕捉细胞的输入输出过程的多维性质。DEA，通过处理细胞作为决策单元，使人们能够引入效率边界的概念，这是密切相关的通量平衡分析的影子价格和有用的估计表型相空间通量的实验测量。
Each living cell needs to solve a resource allocation problem, in which multiple inputs (uptake fluxes) and outputs (secretion fluxes) are the outcome of the stoichiometry of biochemical pathways and the regulation of metabolic enzymes. Quantifying the efficiency with which a cell solves this resource allocation problem constitutes a basic question in “cellular economics.” In this letter, we propose the use of data envelopment analysis (DEA) to define multidimensional yields that can capture the multidimensional nature of cell input–output processes. The DEA, by treating cells as decision-making units, enables one to introduce the concept of efficiency frontier that is both intimately connected to the shadow prices of flux balance analysis and useful to estimate the phenotypic phase space from experimental measurements of fluxes.