Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort.
Rising adiposity curbing decline in the incidence of myocardial infarction: 20-year follow-up of British men and women in the Whitehall II cohort.
复制标题
心肌梗塞发病率的肥胖稳定下降：在怀特霍尔II队列中，英国男女的随访20年。
DOI：
10.1093/eurheartj/ehr142
复制
发表时间：
2012-02
影响因子：
39.3
通讯作者：
Brunner EJ
中科院分区：
文献类型：
--
作者：
Hardoon SL;Morris RW;Whincup PH;Shipley MJ;Britton AR;Masset G;Stringhini S;Sabia S;Kivimaki M;Singh-Manoux A;Brunner EJ
评估风险因素趋势对英国男性和女性心肌梗死（MI）发病率20年下降的贡献。从1985年到2004年，白厅II队列中的6379名男性和3074名女性被随访了MI事件和风险因素趋势。在20年中，年龄-性别调整的MI风险下降了74%（95%置信区间48-87%），相当于平均每年下降6.5%（3.2-9.7%）。34%（20-76%）的MI风险下降可以通过非HDL胆固醇水平下降进行统计学解释，其次是HDL胆固醇升高（17%，10-32%），收缩压降低（13%，7-24%）和吸烟率降低（6%，2-14%）。水果和蔬菜消费量的增加贡献了7%（-1-20%）。综合起来，这五个风险因素解释了56%（34-112%）。身体质量指数（BMI）的上升适得其反，单独减少了11%（5-23%）的下降幅度。男性和女性的MI下降和风险因素的影响似乎相似。在男性和女性中，MI风险下降的一半以上可以归因于有利的风险因素时间趋势。BMI的不利作用强调了解决人口BMI上升的重要性。
To estimate the contribution of risk factor trends to 20-year declines in myocardial infarction (MI) incidence in British men and women. From 1985 to 2004, 6379 men and 3074 women in the Whitehall II cohort were followed for incident MI and risk factor trends. Over 20 years, the age–sex-adjusted hazard of MI fell by 74% (95% confidence interval 48–87%), corresponding to an average annual decline of 6.5% (3.2–9.7%). Thirty-four per cent (20–76%) of the decline in MI hazard could be statistically explained by declining non-HDL cholesterol levels, followed by increased HDL cholesterol (17%, 10–32%), reduced systolic blood pressure (13%, 7–24%), and reduced cigarette smoking prevalence (6%, 2–14%). Increased fruit and vegetable consumption made a non-significant contribution of 7% (−1–20%). In combination, these five risk factors explained 56% (34–112%). Rising body mass index (BMI) was counterproductive, reducing the scale of the decline by 11% (5–23%) in isolation. The MI decline and the impact of the risk factors appeared similar for men and women. In men and women, over half of the decline in MI risk could be accounted for by favourable risk factor time trends. The adverse role of BMI emphasizes the importance of addressing the rising population BMI.
登录
查看更多内容
影响因子：
5
作者：
Prentice, RL;Langer, RD;Wactawski-Wende, J
通讯作者：
Wactawski-Wende, J
影响因子：
2
作者：
Thiébaut, ACM;Bénichou, J
通讯作者：
Bénichou, J
影响因子：
168.9
作者：
Kuulasmaa, K;Tunstall-Pedoe, H;Tuomilehto, J
通讯作者：
Tuomilehto, J
影响因子：
120.7
作者：
Wijeysundera, Harindra C.;Machado, Marcio;Capewell, Simon
通讯作者：
Capewell, Simon
影响因子：
158.5
作者：
Hu, FB;Stampfer, MJ;Willett, WC
通讯作者：
Willett, WC