Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop.
Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop.
复制标题
DOI：
10.20411/pai.v5i1.365
复制
发表时间：
2020-01-01
影响因子：
--
通讯作者：
Hunt, Peter W
中科院分区：
文献类型：
--
作者：
Gabuzda, Dana;Jamieson, Beth D;Hunt, Peter W
HIV感染者（PWH）经历了加重的生物衰老，这是由炎症、免疫功能障碍和表观遗传时钟标记所定义的。他们患多种与年龄相关的合并症的风险也较高。为了讨论艾滋病毒感染治疗中老龄化和年龄相关合并症的当前知识、研究差距和优先事项，美国国立卫生研究院项目工作人员于2019年9月在马里兰州贝塞斯达组织了一次研讨会。这篇综述文章描述了由发病机制/基础科学研究工作组领导的讨论的亮点，重点关注三个高优先主题：免疫发病机制；微生物/ virome;衰老和衰老。我们总结了这些领域的知识，并描述了PWH中衰老和年龄相关合并症的发病机制研究的关键问题。了解生物老化加剧的驱动因素和机制是当务之急，这将有助于确定潜在的治疗靶点，以改善老年PWH患者的健康寿命。
People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also have an elevated risk of multiple age-associated comorbidities. To discuss current knowledge, research gaps, and priorities in aging and age-related comorbidities in treated HIV infection, the NIH program staff organized a workshop held in Bethesda, Maryland in September 2019. This review article describes highlights of discussions led by the Pathogenesis/Basic Science Research working group that focused on three high priority topics: immunopathogenesis; the microbiome/virome; and aging and senescence. We summarize knowledge in these fields and describe key questions for research on the pathogenesis of aging and age-related comorbidities in PWH. Understanding the drivers and mechanisms underlying accentuated biological aging is a high priority that will help identify potential therapeutic targets to improve healthspan in older PWH.