Adiponectin preserves metabolic fitness during aging.
Adiponectin preserves metabolic fitness during aging.
复制标题
脂联素在衰老过程中保持代谢适应性。
DOI：
10.7554/elife.65108
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发表时间：
2021-04-27
期刊：
影响因子：
7.7
通讯作者：
Scherer PE
中科院分区：
文献类型：
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作者：
Li N;Zhao S;Zhang Z;Zhu Y;Gliniak CM;Vishvanath L;An YA;Wang MY;Deng Y;Zhu Q;Shan B;Sherwood A;Onodera T;Oz OK;Gordillo R;Gupta RK;Liu M;Horvath TL;Dixit VD;Scherer PE
脂联素是调节组织基质利用和全身性胰岛素敏感性的重要物质。临床研究表明，循环脂联素与健康和寿命呈正相关。然而，脂联素在促进健康和寿命方面的直接作用尚不清楚。在这里，我们使用脂联素缺失的小鼠和转基因脂联素过表达的模型。我们直接评估了循环脂联素对衰老过程的影响，发现脂联素缺失的小鼠表现出加剧了与年龄相关的糖脂代谢紊乱。此外，脂联素缺失的小鼠在饮食和高脂饮食下的寿命都显著缩短。相比之下，循环脂联素水平升高的转基因小鼠模型显著改善了全身胰岛素敏感性，减少了与年龄相关的组织炎症和纤维化，并延长了健康寿命和中位寿命。这些结果支持了脂联素作为健康和寿命的重要调节因子的作用。
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.