Intermediate filaments: a historical perspective.
Intermediate filaments: a historical perspective.
复制标题
中间长丝：历史视角。
DOI：
10.1016/j.yexcr.2007.04.007
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发表时间：
2007
影响因子：
3.7
通讯作者：
Oshima,RobertG
中科院分区：
文献类型：
--
作者：
Oshima,RobertG
大小介于肌动蛋白微丝和微管之间的细胞内蛋白丝由令人惊讶的多种组织特异性蛋白组成，这些蛋白通常与其他丝状系统互连以实现机械稳定性，并由多种提供特殊功能的蛋白修饰。负责聚合成单个 10 nm 丝的卷曲螺旋、α 螺旋结构的序列保守性定义了中间丝蛋白到一个大基因家族的分类。单个细丝进一步组装成光学显微镜下可见的束和分支细胞骨架。然而，可变末端结构域的多样性可能对不同的功能贡献最大。对中间丝蛋白功能的研究发现了其在皮肤、心脏、肌肉、肝脏、大脑、脂肪组织甚至过早衰老疾病中的作用。中间丝作为组织装饰分子分布的结构元件和支架的用途的多样性与其他细胞骨架元件形成对比。这篇评论试图回顾一下这样一个多元化的领域在大约 30 年来是如何出现和变化的。
Intracellular protein filaments intermediate in size between actin microfilaments and microtubules are composed of a surprising variety of tissue specific proteins commonly interconnected with other filamentous systems for mechanical stability and decorated by a variety of proteins that provide specialized functions. The sequence conservation of the coiled-coil, alpha-helical structure responsible for polymerization into individual 10 nm filaments defines the classification of intermediate filament proteins into a large gene family. Individual filaments further assemble into bundles and branched cytoskeletons visible in the light microscope. However, it is the diversity of the variable terminal domains that likely contributes most to different functions. The search for the functions of intermediate filament proteins has led to discoveries of roles in diseases of the skin, heart, muscle, liver, brain, adipose tissues and even premature aging. The diversity of uses of intermediate filaments as structural elements and scaffolds for organizing the distribution of decorating molecules contrasts with other cytoskeletal elements. This review is an attempt to provide some recollection of how such a diverse field emerged and changed over about 30 years.