Maternal exercise improves insulin sensitivity in mature rat offspring.
Maternal exercise improves insulin sensitivity in mature rat offspring.
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DOI：
10.1249/mss.0b013e31827de953
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发表时间：
2013-05
影响因子：
4.1
通讯作者：
Pearson KJ
中科院分区：
文献类型：
--
作者：
Carter LG;Qi NR;De Cabo R;Pearson KJ
最近的研究结果表明，宫内环境可能会对后代的长期胰岛素敏感性产生负面影响。为了积极主动，我们开始探索母亲自愿运动作为一种干预措施，以改善后代的胰岛素敏感性和葡萄糖稳态。将雌性Sprague道利大鼠分为久坐组和运动组，运动组在交配、妊娠和哺乳之前和期间自愿接近笼中的转轮。将雌性后代断奶至静止笼中。对成年后代进行葡萄糖耐量试验和高胰岛素-正葡萄糖钳夹试验，以评估葡萄糖调节和胰岛素敏感性。与久坐母鼠的后代相比，运动母鼠的成年雌性后代在葡萄糖耐量试验期间具有增强的葡萄糖处置（P < 0.05），以及在高胰岛素-正葡萄糖钳夹试验期间增加的葡萄糖输注速率（P < 0.01）和全身葡萄糖周转率（P < 0.05）。与久坐的母鼠所生的后代相比，运动母鼠的后代在钳夹过程中胰岛素水平（P < 0.01）和肝脏葡萄糖生成（P < 0.05）也有所下降。在钳夹过程中，与久坐不动的母鼠相比，运动母鼠的后代骨骼肌葡萄糖摄取增加（P < 0.05），心脏葡萄糖摄取减少（P < 0.01）。孕期运动可增强后代胰岛素敏感性，改善后代葡萄糖稳态。这可以降低后代对胰岛素抵抗相关疾病如2型糖尿病的易感性。母亲锻炼可能是一种简单、短期、非药物性的预防后代疾病的方法。
Recent findings have shown the intrauterine environment can negatively influence long-term insulin sensitivity in the offspring. In an attempt to be pro-active, we set out to explore maternal voluntary exercise as an intervention in order to improve offspring insulin sensitivity and glucose homeostasis. Female Sprague Dawley rats were split into sedentary and exercise groups with the exercise cohort having voluntary access to a running wheel in the cage prior to and during mating, pregnancy, and nursing. Female offspring were weaned into sedentary cages. Glucose tolerance tests and hyperinsulinemic–euglycemic clamp were performed in adult offspring to evaluate glucose regulation and insulin sensitivity. Adult female offspring born to exercised dams had enhanced glucose disposal during glucose tolerance testing (P < 0.05) as well as increased glucose infusion rates (P < 0.01) and whole body glucose turnover rates (P < 0.05) during hyperinsulinemic–euglycemic clamp testing compared to offspring from sedentary dams. Offspring from exercised dams also had decreased insulin levels (P < 0.01) and hepatic glucose production (P < 0.05) during the clamp procedure compared to offspring born to sedentary dams. Offspring from exercised dams had increased glucose uptake in skeletal muscle (P < 0.05) and decreased heart glucose uptake (P < 0.01) compared to offspring from sedentary dams in response to insulin infusion during the clamp procedure. Exercise during pregnancy enhances offspring insulin sensitivity and improves offspring glucose homeostasis. This can decrease offspring susceptibility to insulin resistant related disease such as type 2 diabetes mellitus. Maternal exercise could be an easy, short–term, non–pharmacological method of preventing disease in future generations.