The cortical NG2-glia response to traumatic brain injury.
The cortical NG2-glia response to traumatic brain injury.
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作者：
创伤性脑损伤（TBI）是世界范围内发病率和死亡率的重要原因。TBI是一种慢性神经系统疾病，被称为“沉默的流行病”，目前还没有靶向治疗来改善细胞损失或增强功能恢复。与星形胶质细胞、小胶质细胞和外周免疫细胞相比，NG 2-胶质细胞在TBI后的功能和机制远未被理解，尽管NG 2-胶质细胞在成熟皮质中包含最大的再生细胞群体。在这里，我们综合了多种啮齿动物TBI模型的结果，重点是皮质NG 2-神经胶质细胞增殖和谱系潜力，并为神经胶质研究人员提出了未来解决TBI中这种独特细胞类型的途径。随着调节NG 2-胶质细胞再生潜力的分子机制的揭示，我们认为未来的治疗策略可能会利用皮质NG 2-胶质细胞来增强TBI后的局部细胞恢复。
Traumatic brain injury (TBI) is a significant worldwide cause of morbidity and mortality. A chronic neurologic disease bearing the moniker of “the silent epidemic”, TBI currently has no targeted therapies to ameliorate cellular loss or enhance functional recovery. Compared to those of astrocytes, microglia, and peripheral immune cells, the functions and mechanisms of NG2-glia following TBI are far less understood, despite NG2-glia comprising the largest population of regenerative cells in the mature cortex. Here, we synthesize the results from multiple rodent models of TBI, with a focus on cortical NG2-glia proliferation and lineage potential, and propose future avenues for glia researchers to address this unique cell type in TBI. As the molecular mechanisms that regulate NG2-glia regenerative potential are uncovered, we posit that future therapeutic strategies may exploit cortical NG2-glia to augment local cellular recovery following TBI.
影响因子：
2.4
作者：
Hossain-Ibrahim, Mohammed K.;Rezajooi, Kia;Stallcup, William B.;Lieberman, Alexander R.;Anderson, Patrick N.
通讯作者：
Anderson, Patrick N.
影响因子：
3.4
作者：
Davidsson J;Risling M
通讯作者：
Risling M